ArticleNeurochemical research2011
Hyperacute detection of neurofilament heavy chain in serum following stroke: a transient sign.
Article in Neurochemical research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Cerebral Infarction: Epidemiology, Classification, Mechanisms, Diagnosis, and Management.MedComm · 2026Review
- Neurofilament Light Chain Correlates with Stroke Severity and Clinical Outcome in Acute Cerebrovascular Stroke Patients.Cellular and molecular neurobiology · 2025Article
- Advances in development of biomarkers for brain damage and ischemia.Molecular biology reports · 2024Review
- Serum neurofilament light chain: a predictive marker for outcomes following mild-to-moderate ischemic stroke.Frontiers in neurology · 2024Article
- Fluid biomarkers of the neurovascular unit in cerebrovascular disease and vascular cognitive disorders: A systematic review and meta-analysis.Cerebral circulation - cognition and behavior · 2024Article
- The 2022 Lady Estelle Wolfson lectureship on neurofilaments.Journal of neurochemistry · 2022Review
- Vasculocentric Axonal NfH in Small Vessel Disease.Journal of neuropathology and experimental neurology · 2022Article
- Prediction of Outcome After Endovascular Embolectomy in Anterior Circulation Stroke Using Biomarkers.Translational stroke research · 2022Article
- Neurofilaments in disease: what do we know?Current opinion in neurobiology · 2020Review
- Serum Neurofilament Light Predicts Severity and Prognosis in Patients with Ischemic Stroke.Neurotoxicity research · 2020Article
- Neurofilaments: The C-Reactive Protein of Neurology.Brain sciences · 2020Review
- Acute Neurofilament Light Chain Plasma Levels Correlate With Stroke Severity and Clinical Outcome in Ischemic Stroke Patients.Frontiers in neurology · 2020Article
- White Matter Injury after Intracerebral Hemorrhage: Pathophysiology and Therapeutic Strategies.Frontiers in human neuroscience · 2017Review
- Neuronal Damage Induced by Perinatal Asphyxia Is Attenuated by Postinjury Glutaredoxin-2 Administration.Oxidative medicine and cellular longevity · 2017Article
- Central and peripheral markers of neurodegeneration and monocyte activation in HIV-associated neurocognitive disorders.Journal of neurovirology · 2015Article
- The back and forth of axonal injury and repair after stroke.Current opinion in neurology · 2014Review
- Neurofilaments as a plasma biomarker for ICU-acquired weakness: an observational pilot study.Critical care (London, England) · 2014Observational
- Increased neurofilament light chain blood levels in neurodegenerative neurological diseases.PloS one · 2013Article
- Serial soluble neurofilament heavy chain in plasma as a marker of brain injury after cardiac arrest.Critical care (London, England) · 2012Article
- The diagnostic and prognostic value of neurofilament heavy chain levels in immune-mediated optic neuropathies.Multiple sclerosis international · 2012Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serological biomarkers which enable quick and reliable diagnosis or measurement of the extent of irreversible brain injury early in the course of stroke are eagerly awaited. Neurofilaments (Nf) are a group of proteins integrated into the scaffolding of the neuronal and axonal cytoskeleton and an established biomarker of neuro-axonal damage. The Nf heavy chain (NfH(SMI35)) was assessed together with brain-specific astroglial proteins GFAP and S100B in hyperacute stroke (6 and 24 h from symptom onset) and daily for up to 6 days. Twenty-two patients with suspected stroke (median NIHSS 8) were recruited in a prospective observational study. Evidence for an ischaemic or haemorrhagic lesion on neuroimaging was found in 18 (ischaemia n = 16, intracerebral haemorrhage n = 2). Serum NfH(SMI35) levels became detectable within 24 h post-stroke (P < 0.0001) and elevated levels persisted over the study course. While GFAP was not detectable during the entire course, S100B levels peaked at the end of the observation period. The data indicate that significant in vivo information on the pathophysiology of stroke may be obtained by the determination of NfH(SMI35). Further studies are required to evaluate whether NfH(SMI35) in hyperacute stroke reflects the extent of focal ischaemic injury seen on neuroimaging or is a consequence of more diffuse neuro-axonal damage.
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