ArticlePsychopharmacology2012
Cue-induced reinstatement of cocaine seeking in the rat "conflict model": effect of prolonged home-cage confinement.
Article in Psychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Relapse after electric barrier-induced voluntary abstinence: A review.Current opinion in neurobiology · 2024Review
- Animal models of compulsion alcohol drinking: Why we love quinine-resistant intake and what we learned from it.Frontiers in psychiatry · 2023Review
- Animal Models of Drug Relapse and Craving after Voluntary Abstinence: A Review.Pharmacological reviews · 2021Review
- Nonhuman animal models of substance use disorders: Translational value and utility to basic science.Drug and alcohol dependence · 2020Review
- Modeling cocaine relapse in rodents: Behavioral considerations and circuit mechanisms.Progress in neuro-psychopharmacology & biological psychiatry · 2018Review
- Pathological Overeating: Emerging Evidence for a Compulsivity Construct.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Review
- Prolonged withdrawal following cocaine self-administration increases resistance to punishment in a cocaine binge.Scientific reports · 2014Article
- Incubation of methamphetamine and palatable food craving after punishment-induced abstinence.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- Drug abstinence: exploring animal models and behavioral treatment strategies.Psychopharmacology · 2014Review
- Rodent models for compulsive alcohol intake.Alcohol (Fayetteville, N.Y.) · 2014Review
- On the motivational properties of reward cues: Individual differences.Neuropharmacology · 2014Review
- Cocaine self-administration punished by i.v. histamine in rat models of high and low drug abuse vulnerability: effects of saccharin preference, impulsivity, and sex.Physiology & behavior · 2013Article
- Cue-evoked cocaine "craving": role of dopamine in the accumbens core.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Cue-induced resumption of heroin and cocaine seeking in rats using a conflict model of abstinence and relapse.Psychopharmacology · 2013Article
- Recent developments in animal models of drug relapse.Current opinion in neurobiology · 2013Article
- Context-induced relapse to alcohol seeking after punishment in a rat model.Biological psychiatry · 2013Article
- The development of a preference for cocaine over food identifies individual rats with addiction-like behaviors.PloS one · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
RATIONALE AND
objectivesDrug addiction is not just the repeated administration of drugs, but compulsive drug use maintained despite the accumulation of adverse consequences for the user. In an attempt to introduce adverse consequences of drug seeking to laboratory animals, we have developed the "conflict model," in which the access of rats to a reinforcing lever allowing self-administration requires passing of an electrified grid floor. In this model, the current intensity leading to complete abstinence from drug seeking can be measured individually. The present study was designed to evaluated whether reinstatement of drug or natural reward seeking, despite the presence of the electrical barrier, can be achieved by presentation of discrete cues that were associated with the reward, and whether prolonged home-cage confinement can facilitate such reinstatement in this model.
methodsThe "conflict model" was used to test cue-induced reinstatement in the presence of the electrical barrier, after 1 or 14 days of home-cage confinement, in groups of rats that were previously trained to self-administer cocaine or sucrose.
resultsAlthough similar shock intensity was required to suppress sucrose or cocaine self-administration, subjects exhibited significantly lower response to sucrose-associated as compared to cocaine-associated cues, during the reinstatement test. Importantly, cue-induced reinstatement of cocaine seeking was attenuated following 14 days of home-cage confinement.
conclusionsThe incorporation of aversive consequence in the self-administration model enable detection of what can be interpreted as a compulsive component unique to drug reinforcers. Moreover, the effect of the aversive consequence seems to increase following home-cage confinement.
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