Evidence map›Paper›PMID 21792540›Full record

ReviewCurrent oncology reports2011

Newly emerging therapies targeting viral-related lymphomas.

Juan Carlos Ramos, Izidore S Lossos

Abstract readReview
In one paragraph

Review in Current oncology reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Juan Carlos RamosDepartment of Medicine, Division of Oncology-Hematology, Sylvester Comprehensive Cancer Center, University of Miami, FL, 33136, USA. jramos2@med.miami.edu
Izidore S Lossos
Sylvester Comprehensive Cancer Center · USUniversity of Miami · US

Funding

University of Southern CaliforniaU01CA121947 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MITSUYASU, RONALD T. · 2006 to 2014
$54.7M
Tissue/Pathology CoreP01CA128115 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI GUETTOUCHE, TOUMY · 2009 to 2013
$5.6M
Significance and Function of HGAL in LymphomaR01CA109335 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI LOSSOS, IZIDORE S · 2005 to 2013
$2.1M
Prognostic Models in Diffuse Large B-Cell LymphomaR01CA122105 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI LOSSOS, IZIDORE S · 2007 to 2010
$1.3M
Targeting of EBV Latency in Burkitt's LymphomaR01CA112217 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI RAMOS, JUAN CARLOS · 2006 to 2010
$1.2M
NCI NIH HHS 1-P01-CA-128115-01A2NCI NIH HHS 2U01CA121947-04NCI NIH HHS CA109335NCI NIH HHS CA122105NCI NIH HHS P01 CA128115NCI NIH HHS R01 CA109335NCI NIH HHS R01 CA112217NCI NIH HHS R01-CA-112217-03NCI NIH HHS R01 CA122105NCI NIH HHS U01 CA121947
6 · The paper itself

Abstract

Gamma-(γ)-herpes virus lymphomas comprise a heterogenous group of B-cell and T-cell neoplasms most commonly associated with Epstein-Barr virus and rarely human herpes virus-8 infection. Adult T-cell leukemia/lymphoma (ATLL) is a unique disease entity caused by the human T-cell lymphotrophic virus, type 1 (HTLV-I), the only retrovirus known to cause cancer in humans. Viral lymphomas behave aggressively and disproportionally affect immunocompromised individuals and those living in underdeveloped regions. These diseases are often difficult to treat with conventional approaches. Despite recent advancements using cytotoxic, lymphoma-specific, and adoptive therapies, the long-term outcome of patients with γ-herpesvirus lymphomas occurring in severely immunocompromised patients and ATLL continues to be poor. Lytic-inducing therapies targeting NF-κB, and viral and tumor cell epigenetic mechanisms afford the advantage of exploiting the intrinsic presence of oncogenic viruses to eradicate infected tumor cells. In this review, viral-related lymphomas and newly emerging clinical approaches targeting viral latency are discussed.

Indexed as

Antineoplastic AgentsAntiviral AgentsHerpesvirus 4, HumanHIVHumansLeukemia-Lymphoma, Adult T-CellLymphoma, AIDS-RelatedLymphoma, B-CellLymphoma, T-CellTumor Virus InfectionsVirus LatencyAntineoplastic AgentsAntiviral Agents

Identifiers

PMID21792540
PMCPMC4041592
OpenAlexW2026017908

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.