ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2011
Patient considerations and clinical utility of a fixed dose combination of saxagliptin/metformin in the treatment of type 2 diabetes.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 27 citations in OpenAlex.
- Long-Term Use of Metformin and Vitamin B12 Deficiency in Diabetes.Current drug safety · 2025Review
- Sulfonylureas and their use in clinical practice.Archives of medical science : AMS · 2015Article
- Adding Saxagliptin to Metformin Extended Release (XR) or Uptitration of Metformin XR: Efficacy on Daily Glucose Measures.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2013Article
- Saxagliptin and metformin in fixed combination for the treatment of type 2 diabetes in adults.Clinical medicine insights. Endocrinology and diabetes · 2013Article
- Metformin and its clinical use: new insights for an old drug in clinical practice.Archives of medical science : AMS · 2012Article
- Therapeutic Experience of Saxagliptin as First Add-on after Metformin in Indian Type 2 Diabetes Patients: A Non-interventional, Prospective, Observational Study (ONTARGET-INDIA).Indian journal of endocrinology and metabolismArticle
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
introductionTargeting glycated hemoglobin (HbA(1c)) levels below 7.0% is considered a primary goal of diabetes care, given its importance in obtaining a sustained reduction in microvascular, and possibly macrovascular complications.
aimThe aim of this review was to evaluate the clinical utility of a fixed dose combination of saxagliptin/metformin in the treatment of type 2 diabetes. EVIDENCE REVIEW: The combination of saxagliptin/metformin was well tolerated and produced sustained glycemic control for up to 76 weeks, with greater improvements in glycemic parameters compared with either drug alone. The saxagliptin/metformin combination also proved its non-inferiority compared with either sulfonylurea/metformin or sitagliptin/metformin combinations. PLACE IN THERAPY: Clinical practice recommends lifestyle interventions together with starting metformin at the time that the type 2 diabetes mellitus is diagnosed. Once metformin fails to maintain glycemic control, the addition of DPP-4 inhibitors should be the logical choice because of their effects on HbA(1c) compared to the addition of a sulfonylurea or glitazone, and because of their positive effects on beta cell function and their neutral effects on body weight. Furthermore, DPP-4 inhibitors prevent the risk of hypoglycemia posed by sulfonylureas.
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