ArticleEuropean journal of human genetics : EJHG2012
Natural positive selection and north-south genetic diversity in East Asia.
Article in European journal of human genetics : EJHG, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis.Human molecular genetics · 2013Pooled it
- Efficiency of trans-ethnic genome-wide meta-analysis and fine-mapping.European journal of human genetics : EJHG · 2012Pooled it
- Global patterns of natural selection inferred using ancient DNA.bioRxiv : the preprint server for biology · 2026Article
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- HLA-Cw1 and Psoriasis.American journal of clinical dermatology · 2021Review
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- Genome-wide analyses reveal footprints of divergent selection and popping-related traits in CIMMYT's maize inbred lines.Journal of experimental botany · 2021Article
- Learning the properties of adaptive regions with functional data analysis.PLoS genetics · 2020Article
- Limited Evidence for Selection at the FADS Locus in Native American Populations.Molecular biology and evolution · 2020Article
- Whole Mitochondrial DNA Sequencing Analysis in 47 Han Populations in Southwest China.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- A Comprehensive Map of Genetic Variation in the World's Largest Ethnic Group-Han Chinese.Molecular biology and evolution · 2018Article
- Architecture of polymorphisms in the human genome reveals functionally important and positively selected variants in immune response and drug transporter genes.Human genomics · 2018Article
- Establishing multiple omics baselines for three Southeast Asian populations in the Singapore Integrative Omics Study.Nature communications · 2017Article
- Characterising private and shared signatures of positive selection in 37 Asian populations.European journal of human genetics : EJHG · 2017Article
- Article
- Genetic structure and differentiation analysis of a Eurasian Uyghur population by use of 27 continental ancestry-informative SNPs.International journal of legal medicine · 2016Article
- Fast Principal-Component Analysis Reveals Convergent Evolution of ADH1B in Europe and East Asia.American journal of human genetics · 2016Article
- Fifteen years of genomewide scans for selection: trends, lessons and unaddressed genetic sources of complication.Molecular ecology · 2016Review
- Mapping the genetic diversity of HLA haplotypes in the Japanese populations.Scientific reports · 2015Article
- Revisiting classic clines in Drosophila melanogaster in the age of genomics.Trends in genetics : TIG · 2015Review
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent reports have identified a north-south cline in genetic variation in East and South-East Asia, but these studies have not formally explored the basis of these clinical differences. Understanding the origins of these variations may provide valuable insights in tracking down the functional variants in genomic regions identified by genetic association studies. Here we investigate the genetic basis of these differences with genome-wide data from the HapMap, the Human Genome Diversity Project and the Singapore Genome Variation Project. We implemented four bioinformatic measures to discover genomic regions that are considerably differentiated either between two Han Chinese populations in the north and south of China, or across 22 populations in East and South-East Asia. These measures prioritized genomic stretches with: (i) regional differences in the allelic spectrum for SNPs common to the two Han Chinese populations; (ii) differential evidence of positive selection between the two populations as quantified by integrated haplotype score (iHS) and cross-population extended haplotype homozygosity (XP-EHH); (iii) significant correlation between allele frequencies and geographical latitudes of the 22 populations. We also explored the extent of linkage disequilibrium variations in these regions, which is important in combining genetic association studies from North and South Chinese. Two of the regions that emerged are found in HLA class I and II, suggesting that the HLA imputation panel from the HapMap may not be directly applicable to every Chinese sample. This has important implications to autoimmune studies that plan to impute the classical HLA alleles to fine map the SNP association signals.
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