ArticleJournal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer2011
Systematic evaluation of genetic variants in three biological pathways on patient survival in low-stage non-small cell lung cancer.
Article in Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 21 citations in OpenAlex.
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- Lung cancer histology classification from CT images based on radiomics and deep learning models.Medical & biological engineering & computing · 2021Article
- Identification and verification of the prognostic value of the glutathione S-transferase Mu genes in gastric cancer.Oncology letters · 2020Article
- Establishment of the Prognostic Index Reflecting Tumor Immune Microenvironment of Lung Adenocarcinoma Based on Metabolism-Related Genes.Journal of Cancer · 2020Article
- Cross-disease analysis identified novel common genes for both lung adenocarcinoma and lung squamous cell carcinoma.Oncology letters · 2019Article
- Effect of GSTP1 and ABCC4 gene polymorphisms on response and toxicity of cyclophosphamide-epirubicin-5-fluorouracil-based chemotherapy in Bangladeshi breast cancer patients.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Candidate pathway-based genetic association study of platinum and platinum-taxane related toxicity in a cohort of primary lung cancer patients.Journal of the neurological sciences · 2015Article
- Article
- Genetic variations and patient-reported quality of life among patients with lung cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2012Article
- Gemcitabine metabolic pathway genetic polymorphisms and response in patients with non-small cell lung cancer.Pharmacogenetics and genomics · 2012Article
- Single nucleotide polymorphisms as susceptibility, prognostic, and therapeutic markers of nonsmall cell lung cancer.Lung Cancer (Auckland, N.Z.) · 2012Review
- Synergistic association of PTGS2 and CYP2E1 genetic polymorphisms with lung cancer risk in northeastern Chinese.PloS one · 2012Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
introductionStudies from selected candidate genes suggest that single-nucleotide polymorphisms (SNPs) involved in glutathione metabolism, DNA repair, or inflammatory responses may affect overall survival (OS) in stages I to II or low-stage non-small cell lung cancer (LS-NSCLC); however, results are inconclusive. In this study, we took a systematic pathway-based approach to simultaneously evaluate the impact of genetic variation from these three pathways on OS after LS-NSCLC diagnosis.
methodsDNA from 647 patients with LS-NSCLC was genotyped for 480 SNPs (tag-SNPs) tagging 57 genes from the three candidate pathways. Associations of tag-SNPs with OS were assessed at the individual SNP and whole gene levels, adjusting for age, tumor stage, surgery type, and adjuvant therapy. The genotype combinations of the SNPs associated with OS were also estimated.
resultsAmong the 412 tag-SNPs that were successfully genotyped and passed quality assessments, 28 showed association with OS (p < 0.05). Two of the 28 were estimated to have less than a 20% chance of being false positives (rs3768490 in GSTM5: p = 1.32 × 10, q = 0.06; rs1729786 in ABCC4: p = 9.25 × 10, q = 0.20). Gene-based analysis suggested that in addition to GSTM5 and ABCC4, variation in two other genes, PTGS2 and GSTA2, was also associated with OS.
conclusionsWe describe further evidence that variations in genes involved in the glutathione and inflammatory response pathways are associated with OS in patients with LS-NSCLC. Further studies are warranted to verify our findings and elucidate their functional mechanisms and clinical utility leading to improved survival for patients with lung cancer.
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