SynthesisNeonatology2012
Biomarkers in neonatal posthemorrhagic hydrocephalus.
Synthesis in Neonatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Elevated TNF-α in cerebrospinal fluid as a potential inflammatory marker in post-hemorrhagic hydrocephalus: a prospective study.Neurosurgical review · 2025Trial
- Cerebrospinal fluid matrix-remodeling biomarkers in neonates with myelomeningocele: MMP-9, TIMP-1, and TGF-β1 expression.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- Advances in biomarkers for predicting outcomes in pediatric neurosurgical hemorrhagic conditions: a narrative review to enhance quality of care.Annals of medicine and surgery (2012) · 2026Review
- Article
- Advancing the management of neonatal hemorrhages: clinical evaluation of external ventricular drainage efficacy.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Early postnatal microglial ablation in the Ccdc39 mouse model reveals adverse effects on brain development and in neonatal hydrocephalus.Fluids and barriers of the CNS · 2023Article
- Functional Hyperconnectivity during a Stories Listening Task in Magnetoencephalography Is Associated with Language Gains for Children Born Extremely Preterm.Brain sciences · 2021Article
- Mesenchymal Stem Cells for Severe Intraventricular Hemorrhage in Preterm Infants: Phase I Dose-Escalation Clinical Trial.Stem cells translational medicine · 2018Article
- Opportunities in posthemorrhagic hydrocephalus research: outcomes of the Hydrocephalus Association Posthemorrhagic Hydrocephalus Workshop.Fluids and barriers of the CNS · 2018Review
- Chemokine and cytokine levels in the lumbar cerebrospinal fluid of preterm infants with post-hemorrhagic hydrocephalus.Fluids and barriers of the CNS · 2017Article
- Stem Cell Therapy for Neonatal Disorders: Prospects and Challenges.Yonsei medical journal · 2017Review
- Article
- Article
- Role of selected cytokines in the etiopathogenesis of intraventricular hemorrhage in preterm newborns.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016Review
- Neural deletion of Tgfbr2 impairs angiogenesis through an altered secretome.Human molecular genetics · 2014Article
- Perinatal biomarkers in prematurity: early identification of neurologic injury.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2014Review
- Morinda citrifolia L. (noni) and memantine attenuate periventricular tissue injury of the fourth ventricle in hydrocephalic rabbits.Neural regeneration research · 2013Article
- Cerebrospinal fluid proteomics identifies calcyphosine and follistatin-like 1 as exploratory candidate proteins of interest in hydrocephalus.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Posthemorrhagic hydrocephalus (PHH) is a rare but serious outcome among premature babies in the NICU, with consequences including mortality and severe neurodevelopmental disabilities. The causes of PHH are still not entirely understood, and its prevention and treatment are controversial. Various cerebrospinal fluid biomarkers have been studied in infants with PHH in order to recognize the causes, diagnose brain injury, and predict neurodevelopmental outcomes. This systematic review summarizes studies on biomarkers of extracellular matrix activity, fibrinolysis/coagulation, hypoxia/cell death, and inflammation in the cerebrospinal fluid of infants with PHH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.