ArticleThe Journal of infectious diseases2011
Chlamydia psittaci genetic variants differ in virulence by modulation of host immunity.
Article in The Journal of infectious diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Global prevalence of psittacosis in outbreaks: a systematic review and meta-analysis.BMC public health · 2025Pooled it
- The relationship betweenFrontiers in medicine · 2026Article
- Investigation of Lethal Concurrent Outbreak of Chlamydiosis and Pigeon Circovirus in a Zoo.Animals : an open access journal from MDPI · 2021Article
- Natural Killer Cells Regulate Pulmonary Macrophages Polarization in Host Defense Against Chlamydial Respiratory Infection.Frontiers in cellular and infection microbiology · 2021Article
- Article
- Genetic variability of T cell responses in hypersensitivity pneumonitis identified using the BXD genetic reference panel.American journal of physiology. Lung cellular and molecular physiology · 2020Article
- Genetic Dissection of the Regulatory Mechanisms ofFrontiers in immunology · 2020Article
- Virulence-related comparative transcriptomics of infectious and non-infectious chlamydial particles.BMC genomics · 2018Article
- Inverse relationship between microRNA-155 and -184 expression with increasing conjunctival inflammation during ocular Chlamydia trachomatis infection.BMC infectious diseases · 2016Article
- The Impact of Protein Phosphorylation on Chlamydial Physiology.Frontiers in cellular and infection microbiology · 2016Review
- Comparable Genital Tract Infection, Pathology, and Immunity in Rhesus Macaques Inoculated with Wild-Type or Plasmid-Deficient Chlamydia trachomatis Serovar D.Infection and immunity · 2015Article
- Chlamydia muridarum infection of macrophages elicits bactericidal nitric oxide production via reactive oxygen species and cathepsin B.Infection and immunity · 2015Article
- In vitro passage selects for Chlamydia muridarum with enhanced infectivity in cultured cells but attenuated pathogenicity in mouse upper genital tract.Infection and immunity · 2015Article
- Genomic variant representation in a Chlamydia population is dynamic and adaptive with dependence on in vitro and in vivo passage.Pathogens and disease · 2015Article
- Plasmid CDS5 influences infectivity and virulence in a mouse model of Chlamydia trachomatis urogenital infection.Infection and immunity · 2014Article
- Plasmid deficiency in urogenital isolates of Chlamydia trachomatis reduces infectivity and virulence in a mouse model.Pathogens and disease · 2014Article
- Plasmid copy number and disease severity in naturally occurring ocular Chlamydia trachomatis infection.Journal of clinical microbiology · 2014Article
- Effect of inflammatory response on in vivo competition between two chlamydial variants in the guinea pig model of inclusion conjunctivitis.Infection and immunity · 2012Article
- Article
- Genome sequences of the zoonotic pathogens Chlamydia psittaci 6BC and Cal10.Journal of bacteriology · 2011Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundPsittacosis is a zoonosis caused by Chlamydia psittaci and is characterized by severe pneumonia and systemic infection. We sought to determine the basis of the 1000-fold difference in lethal dose of 2 C. psittaci 6BC strains in mice.
methodsGenomes of the strains were sequenced. Mice were infected intraperitoneally and the growth kinetics, immune responses, and pathology were compared.
resultsThe 2 strains differed by the presence of a 7.5-kb plasmid in the attenuated strain and 7 nonsynonomous single-nucleotide polymorphisms between the chromosomes, including a serine/threonine protein kinase gene pkn5. The plasmid was cured from the attenuated strain, but it remained nonlethal. Strains did not differ in growth kinetics in vitro or in vivo. Infection with the attenuated strain led to influx of activated macrophages with relatively minor organ damage. In contrast, the virulent strain caused an influx of nonactivated macrophages, neutrophils, and significant end organ damage. Mice infected with the virulent strain survived challenge when coinfected with either the plasmid-positive or plasmid-negative attenuated strain, indicating that an active process elicited by the attenuated strain reduces inflammation and disease.
conclusionsC. psittaci modulates virulence by alteration of host immunity, which is conferred by small differences in the chromosome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.