ArticlePhysiological genomics2011
Transcriptional analysis of the endothelial response to diabetes reveals a role for galectin-3.
Article in Physiological genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Galectin-3 and the Glyco-Inflammatory Axis: A Missing Link to Residual Cardiovascular Risk in Coronary Artery Disease.Biomedicines · 2025Review
- Review
- Galectin-3 protects against ischemic stroke by promoting neuro-angiogenesis via apoptosis inhibition and Akt/Caspase regulation.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Galectins in the Pathogenesis of Common Retinal Disease.Frontiers in pharmacology · 2021Review
- The roles of galectins in hepatic diseases.Journal of molecular histology · 2020Review
- Galectins in the Pathogenesis of Cerebrovascular Accidents: An Overview.Journal of experimental neuroscience · 2019Review
- Galectin-3: One Molecule for an Alphabet of Diseases, from A to Z.International journal of molecular sciences · 2018Review
- Galectin-3 and Venous Thromboembolism Incidence: the Atherosclerosis Risk in Communities (ARIC) Study.Research and practice in thrombosis and haemostasis · 2017Article
- Galectin-3 deficiency exacerbates hyperglycemia and the endothelial response to diabetes.Cardiovascular diabetology · 2015Article
- Increased levels of galectin-3 were associated with prediabetes and diabetes: new risk factor?Journal of endocrinological investigation · 2015Article
- Timing of galectin-1 exposure differentially modulates Nipah virus entry and syncytium formation in endothelial cells.Journal of virology · 2015Article
- Galectin-3: its role in asthma and potential as an anti-inflammatory target.Respiratory research · 2013Review
- Galectin-3 is a regulator of metaflammation in adipose tissue and pancreatic islets.Adipocyte · 2013Article
- Vascular transcriptional alterations produced by juvenile obesity in Ossabaw swine.Physiological genomics · 2013Article
- Galectin-3 deficiency accelerates high-fat diet-induced obesity and amplifies inflammation in adipose tissue and pancreatic islets.Diabetes · 2013Article
- 5-lipoxygenase-activating protein as a modulator of olanzapine-induced lipid accumulation in adipocyte.Journal of lipids · 2013Article
- Mouse models and techniques for the isolation of the diabetic endothelium.ISRN endocrinology · 2013Article
- Increased adiposity, dysregulated glucose metabolism and systemic inflammation in Galectin-3 KO mice.PloS one · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
To characterize the endothelial dysfunction associated with Type II diabetes, we surveyed transcriptional responses in the vascular endothelia of mice receiving a diabetogenic, high-fat diet. Tie2-GFP mice were fed a diet containing 60% fat calories (HFD); controls were littermates fed normal chow. Following 4, 6, and 8 wk, aortic and leg muscle tissues were enzymatically dispersed, and endothelial cells were obtained by fluorescence-activated cell sorting. Relative mRNA abundance in HFD vs. control endothelia was measured with long-oligo microarrays; highly dysregulated genes were confirmed by real-time PCR and protein quantification. HFD mice were hyperglycemic by 2 wk and displayed vascular insulin resistance and decreased glucose tolerance by 5 and 6 wk, respectively. Endothelial transcripts upregulated by HFD included galectin-3 (Lgals3), 5-lipoxygenase-activating protein, and chemokine ligands 8 and 9. Increased LGALS3 protein was detected in muscle endothelium by immunohistology accompanied by elevated LGALS3 in the serum of HFD mice. Our comprehensive analysis of the endothelial transcriptional response in a model of Type II diabetes reveals novel regulation of transcripts with roles in inflammation, insulin sensitivity, oxidative stress, and atherosclerosis. Increased endothelial expression and elevated humoral levels of LGALS3 supports a role for this molecule in the vascular response to diabetes, and its potential as a direct biomarker for the inflammatory state in diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.