ArticlePlant physiology2011
Essential role of tissue-specific proline synthesis and catabolism in growth and redox balance at low water potential.
Article in Plant physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 139 papers.
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Who cites it
139 citing papers in PubMed, 374 citations in OpenAlex.
- Evolutionary and Structural Insights into Proline Metabolism Genes Associated with Salt Resilience in Mango.Biochemical genetics · 2026Article
- Symbiotic interactions of dark septate endophytic fungi on shallot growth under drought stress.Archives of microbiology · 2026Article
- Elevated COMycorrhiza · 2026Article
- Proline treatment improves salinity tolerance in the green microalga Dunaliella sp. by altering carbon partitioning and inducing metabolites accumulation.Folia microbiologica · 2026Article
- Regulation of redox homeostasis and proline metabolism by tea polyphenols ameliorates salinity tolerance during wheat seed germination and early seedling growth.BMC plant biology · 2026Article
- Comparative efficacy of gibberellic acid and melatonin seed priming on germination and biochemical responses of maize under drought stress.Frontiers in plant science · 2026Article
- Redox homeostasis under summer stress: targeted ROS modulation by foliar kaolin-silicon mixtures inFrontiers in plant science · 2026Article
- Integrating multiomic resources and gene expression studies to identify candidates for engineering climate-resilientFrontiers in plant science · 2026Review
- Measurement of δMetabolites · 2025Article
- Assessment of Drought Tolerance Degree (DTD) method as a reliable tool for early-stage screening for drought tolerance in indica rice.BMC plant biology · 2025Article
- Strigolactones enhance apple drought resistance via the MsABI5-MsSMXL1-MsNAC022 cascade.Horticulture research · 2025Article
- The Effect of Heat Stress on Wheat Flag Leaves Revealed by Metabolome and Transcriptome Analyses During the Reproductive Stage.International journal of molecular sciences · 2025Article
- High throughput screening and evaluation of salt-tolerant mutants from an EMS collection ofFrontiers in plant science · 2025Article
- Proline and ROS: A Unified Mechanism in Plant Development and Stress Response?Plants (Basel, Switzerland) · 2024Review
- Comparative Transcriptome Analysis Revealing the Potential Salt Tolerance Mechanism of Exogenous Abscisic Acid Application inInternational journal of molecular sciences · 2024Article
- Transcriptome-Based Spatiotemporal Analysis of Drought Response Mechanisms in Two Distinct Peanut Cultivars.International journal of molecular sciences · 2024Article
- Proline metabolism is essential for alkaline adaptation of Nile tilapia (Oreochromis niloticus).Journal of animal science and biotechnology · 2024Article
- The role of salicylic acid in modulating phenotyping in spring wheat varieties for mitigating drought stress.BMC plant biology · 2024Article
- The nonphototrophic hypocotyl 3 (NPH3) domain protein NRL5 is a trafficking-associated GTPase essential for drought resistance.Science advances · 2024Article
- Proline Metabolism Genes in Transgenic Plants: Meta-Analysis under Drought and Salt Stress.Plants (Basel, Switzerland) · 2024Article
79 more citing papers are in PubMed but not listed here.
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3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To better define the still unclear role of proline (Pro) metabolism in drought resistance, we analyzed Arabidopsis (Arabidopsis thaliana) Δ(1)-pyrroline-5-carboxylate synthetase1 (p5cs1) mutants deficient in stress-induced Pro synthesis as well as proline dehydrogenase (pdh1) mutants blocked in Pro catabolism and found that both Pro synthesis and catabolism were required for optimal growth at low water potential (ψ(w)). The abscisic acid (ABA)-deficient mutant aba2-1 had similar reduction in root elongation as p5cs1 and p5cs1/aba2-1 double mutants. However, the reduced growth of aba2-1 but not p5cs1/aba2-1 could be complemented by exogenous ABA, indicating that Pro metabolism was required for ABA-mediated growth protection at low ψ(w). PDH1 maintained high expression in the root apex and shoot meristem at low ψ(w) rather than being repressed, as in the bulk of the shoot tissue. This, plus a reduced oxygen consumption and buildup of Pro in the root apex of pdh1-2, indicated that active Pro catabolism was needed to sustain growth at low ψ(w). Conversely, P5CS1 expression was most highly induced in shoot tissue. Both p5cs1-4 and pdh1-2 had a more reduced NADP/NADPH ratio than the wild type at low ψ(w). These results indicate a new model of Pro metabolism at low ψ(w) whereby Pro synthesis in the photosynthetic tissue regenerates NADP while Pro catabolism in meristematic and expanding cells is needed to sustain growth. Tissue-specific differences in Pro metabolism and function in maintaining a favorable NADP/NADPH ratio are relevant to understanding metabolic adaptations to drought and efforts to enhance drought resistance.
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