ArticleBlood2011
Homeostatic cytokines orchestrate the segregation of CD4 and CD8 memory T-cell reservoirs in mice.
Article in Blood, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- IL-15 overexpression promotes memory program and anti-tumor activity of CD64 CAR T cells in a preclinical AML model.Communications biology · 2026Article
- Eomesodermin driven IL-10 production in effector CD8Cellular immunology · 2019Article
- CD4+ Memory T Cells at Home in the Tissue: Mechanisms for Health and Disease.Frontiers in immunology · 2018Review
- Article
- Transcriptional Immunoprofiling at the Tick-Virus-Host Interface during Early Stages of Tick-Borne Encephalitis Virus Transmission.Frontiers in cellular and infection microbiology · 2017Article
- MicroRNA-146a Overexpression Impairs the Positive Selection during T Cell Development.Frontiers in immunology · 2017Article
- Tissue-resident memory T cells: local specialists in immune defence.Nature reviews. Immunology · 2016Review
- CD4 T-cell memory generation and maintenance.Critical reviews in immunology · 2014Review
- The developmental pathway for CD103(+)CD8+ tissue-resident memory T cells of skin.Nature immunology · 2013Article
- IL-18-based combinatorial adjuvants promote the intranodal production of CCL19 by NK cells and dendritic cells of cancer patients.Oncoimmunology · 2013Article
- Hoxb4 overexpression in CD4 memory phenotype T cells increases the central memory population upon homeostatic proliferation.PloS one · 2013Article
- Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Local immunity by tissue-resident CD8(+) memory T cells.Frontiers in immunology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Memory T cells (T(M)s) have been detected in many tissues but their quantitative distribution remains largely undefined. We show that in mice there is a remarkably biased accumulation of long-term CD4 T(M)s into mucosal sites (mainly gut, especially Peyer patches), and CD8 T(M)s into lymph nodes and spleen (in particular, peripheral lymph nodes [PLNs]). This distinction correlates with their differentiated expression of PLN- and gut-homing markers. CD8 and CD4 T(M)s selectively require the expression of PLN-homing marker CCR7 or gut-homing marker α4β7 for maintenance. PLNs and gut supply CD8 and CD4 T(M)s with their individually favored homeostatic cytokine, IL-15, or IL-7. Cytokine stimulation in turn regulates the different gut-homing marker expression on CD4 and CD8 T(M)s. IL-15 plays a major role in vivo regulating CD8 T(M)s homing to PLNs. Thus, the reservoir segregation of CD4 and CD8 T(M)s meets their individual needs for homeostatic cytokines and is under feedback control of cytokine stimulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.