ArticleBlood2011
Identification of Flt3⁺CD150⁻ myeloid progenitors in adult mouse bone marrow that harbor T lymphoid developmental potential.
Article in Blood, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Lineage switch in leukemia and lymphoma: case reports and molecular and cellular mechanisms.Blood neoplasia · 2026Review
- 9-O-acetyl sialic acid levels identify committed progenitors of plasmacytoid dendritic cells.Glycobiology · 2019Article
- miRNAs in Normal and Malignant Hematopoiesis.International journal of molecular sciences · 2017Review
- Interleukin-21 promotes thymopoiesis recovery following hematopoietic stem cell transplantation.Journal of hematology & oncology · 2017Article
- Selective Expression of Flt3 within the Mouse Hematopoietic Stem Cell Compartment.International journal of molecular sciences · 2017Article
- An Atypical Splenic B Cell Progenitor Population Supports Antibody Production during Plasmodium Infection in Mice.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Distinct myeloid progenitor-differentiation pathways identified through single-cell RNA sequencing.Nature immunology · 2016Article
- TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow.Nature immunology · 2015Article
- Review
- Developmental gene networks: a triathlon on the course to T cell identity.Nature reviews. Immunology · 2014Review
- Article
- The Impact of FLT3 Mutations on the Development of Acute Myeloid Leukemias.Leukemia research and treatment · 2013Article
- Genetic regulation of thymocyte progenitor aging.Seminars in immunology · 2012Review
- Would cancer stem cells affect the future investment in stem cell therapy.World journal of experimental medicine · 2012Review
- Replenishing B lymphocytes in health and disease.Current opinion in immunology · 2012Review
- The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential.Nature immunology · 2012Article
- Clinical and molecular characterization of early T-cell precursor leukemia: a high-risk subgroup in adult T-ALL with a high frequency of FLT3 mutations.Blood cancer journal · 2012Article
- Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Common myeloid progenitors (CMPs) were first identified as progenitors that were restricted to myeloid and erythroid lineages. However, it was recently demonstrated that expression of both lymphoid- and myeloid-related genes could be detected in myeloid progenitors. Furthermore, these progenitors were able to give rise to T and B lymphocytes, in addition to myeloid cells. Yet, it was not known whether these progenitors were multipotent at the clonogenic level or there existed heterogeneity within these progenitors with different lineage potential. Here we report that previously defined CMPs possess T-lineage potential, and that this is exclusively found in the Flt3(+)CD150(-) subset of CMPs at the clonal level. In contrast, we did not detect B-lineage potential in CMP subsets. Therefore, these Flt3(+)CD150(-) myeloid progenitors were T/myeloid potent. Yet, Flt3(+)CD150(-) myeloid progenitors are not likely to efficiently traffic to the thymus and contribute to thymopoiesis under normal conditions because of the lack of CCR7 and CCR9 expression. Interestingly, both Flt3(+)CD150(-) and Flt3(-)CD150(-) myeloid progenitors are susceptible to Notch1-mediated T-cell acute lymphoblastic leukemia (T-ALL). Hence, gain-of-function Notch1 mutations occurring in developing myeloid progenitors, in addition to known T-lineage progenitors, could lead to T-ALL oncogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.