ArticleNeuron2011
Pathway-specific genetic attenuation of glutamate release alters select features of competition-based visual circuit refinement.
Article in Neuron, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 64 citations in OpenAlex.
- Article
- Eye-specific differences in active zone addition during synaptic competition in the developing visual system.bioRxiv : the preprint server for biology · 2025Article
- Article
- Article
- Development of the Binocular Circuit.Annual review of neuroscience · 2024Review
- Mapping the Retina onto the Brain.Cold Spring Harbor perspectives in biology · 2024Review
- Semaphorin-6D and Plexin-A1 Act in a Non-Cell-Autonomous Manner to Position and Target Retinal Ganglion Cell Axons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Interactions between rodent visual and spatial systems during navigation.Nature reviews. Neuroscience · 2023Review
- Structural and Functional Plasticity in the Dorsolateral Geniculate Nucleus of Mice following Bilateral Enucleation.Neuroscience · 2022Article
- A cell-ECM mechanism for connecting the ipsilateral eye to the brain.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Loss of P2Y12 Has Behavioral Effects in the Adult Mouse.International journal of molecular sciences · 2021Article
- Retinal Axon Interplay for Binocular Mapping.Frontiers in neural circuits · 2021Article
- A Zic2-regulated switch in a noncanonical Wnt/βcatenin pathway is essential for the formation of bilateral circuits.Science advances · 2020Article
- Spatiotemporal distribution of glia in and around the developing mouse optic tract.The Journal of comparative neurology · 2019Article
- Article
- Eye-specific segregation and differential fasciculation of developing retinal ganglion cell axons in the mouse visual pathway.The Journal of comparative neurology · 2018Article
- Article
- RIM1/2 in retinal ganglion cells are required for the refinement of ipsilateral axons and eye-specific segregation.Scientific reports · 2017Article
- Organization of the dorsal lateral geniculate nucleus in the mouse.Visual neuroscience · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
A hallmark of mammalian neural circuit development is the refinement of initially imprecise connections by competitive activity-dependent processes. In the developing visual system retinal ganglion cell (RGC) axons from the two eyes undergo activity-dependent competition for territory in the dorsal lateral geniculate nucleus (dLGN). The direct contributions of synaptic transmission to this process, however, remain unclear. We used a genetic approach to reduce glutamate release selectively from ipsilateral-projecting RGCs and found that their release-deficient axons failed to exclude competing axons from the ipsilateral eye territory in the dLGN. Nevertheless, the release-deficient axons consolidated and maintained their normal amount of dLGN territory, even in the face of fully active competing axons. These results show that during visual circuit refinement glutamatergic transmission plays a direct role in excluding competing axons from inappropriate target regions, but they argue that consolidation and maintenance of axonal territory are largely insensitive to alterations in synaptic activity levels.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.