Evidence map›Paper›PMID 21791282›Full record

ReviewNeuron2011

Consolidation and reconsolidation: two lives of memories?

Sam McKenzie, Howard Eichenbaum

Open access · bronzeAbstract readReview
In one paragraph

Review in Neuron, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 139 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
139citing papers in PubMed, 2 pooled it
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

139 citing papers in PubMed, 2 syntheses or guidelines pooled it, 346 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Intrusions in episodic memory: reconsolidation or interference?Learning & memory (Cold Spring Harbor, N.Y.) · 2017
    Trial
  4. Hippocampal binding of novel information with dominant memory traces can support both memory stability and change.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014
    Trial
  5. Article
  6. Article
  7. Spaces and sequences in the hippocampus: a homological perspective.Journal of computational neuroscience · 2026
    Article
  8. Article
  9. A prelimbic molecular clock of protein synthesis for memory persistence.bioRxiv : the preprint server for biology · 2026
    Article
  10. Article
  11. Current state of 'lost in the mall': implications for expert witness testimony on the reliability of childhood memories.Psychiatry, psychology, and law : an interdisciplinary journal of the Australian and New Zealand Association of Psychiatry, Psychology and Law · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article

79 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sam McKenzieCenter for Memory and Brain, Boston University, Boston, MA 02215, USA.
Howard Eichenbaum
Boston University · US

Funding

Models of behavior and spike timing in sequence memoryP50MH071702 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI EICHENBAUM, HOWARD B. · 2006 to 2010
$8.8M
COMPARATIVE COGNITION AND HIPPOCAMPAL FUNCTIONR01MH052090 · NIMH · STATE UNIVERSITY NEW YORK STONY BROOK · PI HASSELMO, MICHAEL E · 1994 to 2020
$6.4M
HIPPOCAMPAL AND CORTICAL CODING IN MEMORYR01MH051570 · NIMH · STATE UNIVERSITY NEW YORK STONY BROOK · PI HASSELMO, MICHAEL E · 1995 to 2018
$6.0M
NIMH NIH HHS MH51570NIMH NIH HHS MH71702NIMH NIH HHS P50 MH071702NIMH NIH HHS R01 MH052090
6 · The paper itself

Abstract

Most studies on memory consolidation consider the new information as if it were imposed on a tabula rasa, but considerable evidence indicates that new memories must be interleaved within a large network of relevant pre-existing knowledge. Early studies on reconsolidation highlighted that a newly consolidated memory could be erased after reactivation, but new evidence has shown that an effective reactivation experience must also involve memory reorganization to incorporate new learning. The combination of these observations on consolidation and reconsolidation highlights the fundamental similarities of both phenomena as the integration of new information and old, and it suggests reconsolidation = consolidation as a neverending process of schema modification.

Indexed as

AnimalsBrainHumansMemoryModels, BiologicalNeural Pathways

Identifiers

PMID21791282
PMCPMC3145971
OpenAlexW1995759170

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.