ArticleBMC genomics2011
A gene-rich, transcriptionally active environment and the pre-deposition of repressive marks are predictive of susceptibility to KRAB/KAP1-mediated silencing.
Article in BMC genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- Article
- Inhibition of HIV-1 gene transcription by KAP1 in myeloid lineage.Scientific reports · 2021Article
- Targeted Chromatinization and Repression of HIV-1 Provirus Transcription with Repurposed CRISPR/Cas9.Viruses · 2020Article
- KAP1-associated transcriptional inhibitory complex regulates C2C12 myoblasts differentiation and mitochondrial biogenesis via miR-133a repression.Cell death & disease · 2020Article
- Genome-wide identification of genes regulating DNA methylation using genetic anchors for causal inference.Genome biology · 2020Article
- Article
- Targeted epigenetic repression of a lymphoma oncogene by sequence-specific histone modifiers induces apoptosis in DLBCL.Leukemia & lymphoma · 2017Article
- Characterization of How DNA Modifications Affect DNA Binding by C2H2 Zinc Finger Proteins.Methods in enzymology · 2016Article
- KAPtain in charge of multiple missions: Emerging roles of KAP1.World journal of biological chemistry · 2014Review
- KAP1 represses differentiation-inducible genes in embryonic stem cells through cooperative binding with PRC1 and derepresses pluripotency-associated genes.Molecular and cellular biology · 2014Article
- Direct non-productive HIV-1 infection in a T-cell line is driven by cellular activation state and NFκB.Retrovirology · 2014Article
- [A KRAB/KAP1-miRNA cascade regulates erythropoiesis through stage-specific control of mitophagy].Medecine sciences : M/S · 2014Article
- DNA recognition of 5-carboxylcytosine by a Zfp57 mutant at an atomic resolution of 0.97 Å.Biochemistry · 2013Article
- KRAB-Zinc Finger Proteins: A Repressor Family Displaying Multiple Biological Functions.Current genomics · 2013Article
- A common mode of recognition for methylated CpG.Trends in biochemical sciences · 2013Review
- Quantitation of HIV DNA integration: effects of differential integration site distributions on Alu-PCR assays.Journal of virological methods · 2013Article
- A resurrected mammalian hAT transposable element and a closely related insect element are highly active in human cell culture.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The KRAB zinc finger protein RSL1 regulates sex- and tissue-specific promoter methylation and dynamic hormone-responsive chromatin configuration.Molecular and cellular biology · 2012Article
- The Krüppel-associated box repressor domain can induce reversible heterochromatization of a mouse locus in vivo.The Journal of biological chemistry · 2012Article
- Human more complex than mouse at cellular level.PloS one · 2012Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundKRAB-ZFPs (Krüppel-associated box domain-zinc finger proteins) are vertebrate-restricted transcriptional repressors encoded in the hundreds by the mouse and human genomes. They act via an essential cofactor, KAP1, which recruits effectors responsible for the formation of facultative heterochromatin. We have recently shown that KRAB/KAP1 can mediate long-range transcriptional repression through heterochromatin spreading, but also demonstrated that this process is at times countered by endogenous influences.
methodTo investigate this issue further we used an ectopic KRAB-based repressor. This system allowed us to tether KRAB/KAP1 to hundreds of euchromatic sites within genes, and to record its impact on gene expression. We then correlated this KRAB/KAP1-mediated transcriptional effect to pre-existing genomic and chromatin structures to identify specific characteristics making a gene susceptible to repression.
resultsWe found that genes that were susceptible to KRAB/KAP1-mediated silencing carried higher levels of repressive histone marks both at the promoter and over the transcribed region than genes that were insensitive. In parallel, we found a high enrichment in euchromatic marks within both the close and more distant environment of these genes.
conclusionTogether, these data indicate that high levels of gene activity in the genomic environment and the pre-deposition of repressive histone marks within a gene increase its susceptibility to KRAB/KAP1-mediated repression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.