ArticleBMC cardiovascular disorders2011
Adherence with statins in a real-life setting is better when associated cardiovascular risk factors increase: a cohort study.
Article in BMC cardiovascular disorders, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Trial
- The Dynamics of Cardiovascular Risk-An Analysis of the Prospective Urban Rural Epidemiology (PURE) Poland Cohort Study.Journal of clinical medicine · 2024Article
- Persistence and Adherence to Cardiovascular Medicines in Australia.Journal of the American Heart Association · 2023Article
- Medication Adherence for Haemophilia Patients: Outcome of Prophylaxis Treatment Intervention.Healthcare (Basel, Switzerland) · 2021Article
- Determinants of Non-Adherence to the Medications for Dyslipidemia: A Systematic Review.Patient preference and adherence · 2021Review
- Real-world evaluation of the impact of statin intensity on adherence and persistence to therapy: A Scottish population-based study.British journal of clinical pharmacology · 2020Article
- Treatment gaps and potential cardiovascular risk reduction from expanded statin use in the US and England.PloS one · 2018Article
- Medication adherence in chronic illness: do beliefs about medications play a role?Patient preference and adherence · 2018Article
- Factors Affecting Adherence to Statins in Hypercholesterolemic Kuwaiti Patients: A Cross-Sectional Study.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2017Article
- Using Classification and Regression Trees (CART) to Identify Prescribing Thresholds for Cardiovascular Disease.PharmacoEconomics · 2016Article
- Residual cardiovascular risk in patients who received lipid-lowering treatment in a real-life setting: retrospective study.ClinicoEconomics and outcomes research : CEOR · 2016Article
- Mortality and recurrence risk in relation to the use of lipid-lowering drugs in a prospective breast cancer patient cohort.PloS one · 2013Article
- How do we improve patient compliance and adherence to long-term statin therapy?Current atherosclerosis reports · 2013Review
- Article
- Assessment of Medication Adherence in Patients with Chronic Diseases in Tabuk, Kingdom of Saudi Arabia.Journal of research in pharmacy practiceArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhile the factors for poor adherence for treatment with statins have been highlighted, the impact of their combination on adherence is not clear.
aimsTo estimate adherence for statins and whether it differs according to the number of cardiovascular risk factors.
methodsA cohort study was conducted using data from the main French national health insurance system reimbursement database. Newly treated patients with statins between September 1 and December 31, 2004 were included. Patients were followed up 15 months. The cohort was split into three groups according to their number of additional cardiovascular risk factors that included age and gender, diabetes mellitus and cardiovascular disease (using co-medications as a proxy). Adherence was assessed for each group by using four parameters: (i) proportion of days covered by statins, (ii) regularity of the treatment over time, (iii) persistence, and (iv) the refill delay.
results16,397 newly treated patients were identified. Of these statin users, 21.7% did not have additional cardiovascular risk factors. Thirty-one percent had two cardiovascular risk factors and 47% had at least three risk factors. All the parameters showed a sub-optimal adherence whatever the group: days covered ranged from 56% to 72%, regularity ranged from 23% to 33% and persistence ranged from 44% to 59%, but adherence was better for those with a higher number of cardiovascular risk factors.
conclusionsThe results confirm that long-term drug treatments are a difficult challenge, particularly in patients at lower risk and invite to the development of therapeutic education.
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