ArticleStress (Amsterdam, Netherlands)2012
Behaviorally inhibited temperament is associated with severity of post-traumatic stress disorder symptoms and faster eyeblink conditioning in veterans.
Article in Stress (Amsterdam, Netherlands), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 58 citations in OpenAlex.
- Trial
- Weaker situations: Uncertainty reveals individual differences in learning: Implications for PTSD.Cognitive, affective & behavioral neuroscience · 2023Review
- Structural differences in the hippocampus and amygdala of behaviorally inhibited macaque monkeys.Hippocampus · 2021Article
- A parent-report scale of behavioral inhibition: Validation and application to preschool-age children who do and do not stutter.Journal of fluency disorders · 2020Article
- Partial Predictability in Avoidance Acquisition and Expression of Wistar-Kyoto and Sprague-Dawley Rats: Implications for Anxiety Vulnerability in Uncertain Situations.Frontiers in psychiatry · 2020Article
- Enhanced Acquisition and Retention of Conditioned Eyeblink Responses in Veterans Expressing PTSD Symptoms: Modulation by Lifetime History of Mild Traumatic Brain Injury.Frontiers in behavioral neuroscience · 2020Article
- Cardiorespiratory Response to Moderate Hypercapnia in Female College Students Expressing Behaviorally Inhibited Temperament.Frontiers in neuroscience · 2020Article
- Inhibited Personality Temperaments Translated Through Enhanced Avoidance and Associative Learning Increase Vulnerability for PTSD.Frontiers in psychology · 2019Review
- Sex differences in a rabbit eyeblink conditioning model of PTSD.Neurobiology of learning and memory · 2018Article
- Article
- Greater avoidance behavior in individuals with posttraumatic stress disorder symptoms.Stress (Amsterdam, Netherlands) · 2017Article
- Post-traumatic stress disorder symptom burden and gender each affect generalization in a reward- and punishment-learning task.PloS one · 2017Article
- Beyond Behavioral Inhibition: A Computer Avatar Task Designed to Assess Behavioral Inhibition Extends to Harm Avoidance.Frontiers in psychology · 2017Article
- Stress-Related Mental Health Symptoms in Coast Guard: Incidence, Vulnerability, and Neurocognitive Performance.Frontiers in psychology · 2017Article
- Watch what I do, not what I say I do: Computer-based avatars to assess behavioral inhibition, a vulnerability factor for anxiety disorders.Computers in human behavior · 2016Article
- On the Complexity of Brain Disorders: A Symptom-Based Approach.Frontiers in computational neuroscience · 2016Article
- Enhanced Eyeblink Conditioning in Behaviorally Inhibited Individuals is Disrupted by Proactive Interference Following US Alone Pre-exposures.Frontiers in behavioral neuroscience · 2016Article
- Testing the role of reward and punishment sensitivity in avoidance behavior: a computational modeling approach.Behavioural brain research · 2015Article
- Increased generalization of learned associations is related to re-experiencing symptoms in veterans with symptoms of post-traumatic stress.Stress (Amsterdam, Netherlands) · 2015Article
- Investigating the Role of Hippocampal BDNF in Anxiety Vulnerability Using Classical Eyeblink Conditioning.Frontiers in psychiatry · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Prior studies have sometimes demonstrated facilitated acquisition of classically conditioned responses and/or resistance to extinction in post-traumatic stress disorder (PTSD). However, it is unclear whether these behaviors are acquired as a result of PTSD or exposure to trauma, or reflect preexisting risk factors that confer vulnerability for PTSD. Here, we examined classical eyeblink conditioning and extinction in veterans self-assessed for current PTSD symptoms, exposure to combat, and the personality trait of behavioral inhibition (BI), a risk factor for PTSD. A total of 128 veterans were recruited (mean age 51.2 years; 13.3% female); 126 completed self-assessment, with 25.4% reporting a history of exposure to combat and 30.9% reporting current, severe PTSD symptoms (PTSS). The severity of PTSS was correlated with current BI (R(2) = 0.497) and PTSS status could be predicted based on current BI and combat history (80.2% correct classification). A subset of the veterans (n = 87) also completed the eyeblink conditioning study. Among veterans without PTSS, childhood BI was associated with faster acquisition; veterans with PTSS showed delayed extinction, under some conditions. These data demonstrate a relationship between current BI and PTSS, and indicate that the facilitated conditioning sometimes observed in patients with PTSD may partially reflect personality traits such as childhood BI that pre-date and contribute to vulnerability for PTSD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.