ReviewJournal of toxicology and environmental health. Part B, Critical reviews2011
Early developmental actions of endocrine disruptors on the hypothalamus, hippocampus, and cerebral cortex.
Review in Journal of toxicology and environmental health. Part B, Critical reviews, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 81 citations in OpenAlex.
- Environmental endocrine disruptors at the synapse: mechanisms linking chemical exposure to cognitive and behavioral dysfunction.Frontiers in behavioral neuroscience · 2026Review
- Astrocytic regulation in hippocampal CA2 mediates the impact of sleep deprivation on spatial working memory.Frontiers in systems neuroscience · 2026Article
- Early-life exposure to PCBs and PFAS exerts negative effects on the developing central nervous system.Journal of hazardous materials · 2025Review
- Gestational exposure to environmental chemical mixtures and cognitive abilities in children: A pooled analysis of two North American birth cohorts.Environment international · 2025Article
- LncRNA-mRNA integrated networks in the neuroendocrine system of bisphenol a-treated mice induce cellular dysfunctions by disrupting transcriptional homeostasis.Animal cells and systems · 2025Article
- Thyroid-on-a-Chip: An Organoid Platform for In Vitro Assessment of Endocrine Disruption.Advanced healthcare materials · 2023Article
- Application of Transgenic Zebrafish Models for Studying the Effects of Estrogenic Endocrine Disrupting Chemicals on Embryonic Brain Development.Frontiers in pharmacology · 2022Review
- Intestinal Flora-Derived Kynurenic Acid Protects Against Intestinal Damage Caused byFrontiers in microbiology · 2022Article
- Review
- Prenatal phthalate exposures and executive function in preschool children.Environment international · 2021Article
- Endocrine disruptors also function as nervous disruptors and can be renamed endocrine and nervous disruptors (ENDs).Toxicology reports · 2021Review
- Immune and Nervous Systems Interaction in Endocrine Disruptors Toxicity: The Case of Atrazine.Frontiers in toxicology · 2021Review
- Sex-specific neurotoxic effects of early-life exposure to fluoride: A review of the epidemiologic and animal literature.Current epidemiology reports · 2020Article
- Early postnatal decabromodiphenyl ether exposure reduces thyroid hormone and astrocyte density in the juvenile mouse dentate gyrus.Physiology & behavior · 2020Article
- Thyroid-disrupting chemicals and brain development: an update.Endocrine connections · 2018Review
- Evidence of the Possible Harm of Endocrine-Disrupting Chemicals in Humans: Ongoing Debates and Key Issues.Endocrinology and metabolism (Seoul, Korea) · 2018Review
- Sensitive periods of substance abuse: Early risk for the transition to dependence.Developmental cognitive neuroscience · 2017Review
- Association of breast adipose tissue levels of polychlorinated biphenyls and breast cancer development in women from Chaoshan, China.Environmental science and pollution research international · 2017Article
- Developmental neurotoxicity of succeeding generations of insecticides.Environment international · 2017Review
- Early exposure to Aroclor 1254 in vivo disrupts the functional synaptic development of newborn hippocampal granule cells.The European journal of neuroscience · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Sex steroids and thyroid hormones play a key role in the development of the central nervous system. The critical role of these hormonal systems may explain the sensitivity of the hypothalamus, the cerebral cortex, and the hippocampus to endocrine-disrupting chemicals (EDC). This review examines the evidence for endocrine disruption of glial-neuronal functions in the hypothalamus, hippocampus, and cerebral cortex. Focus was placed on two well-studied EDC, the insecticide dichlorodiphenyltrichloroethane (DDT) and polychlorinated biphenyls (PCB). DDT is involved in neuroendocrine disruption of the reproductive axis, whereas polychlorinated biphenyls (PCB) interact with both the thyroid hormone- and sex steroid-dependent systems and disturb the neuroendocrine control of reproduction and development of hippocampus and cortex. These results highlight the impact of EDC on the developing nervous system and the need for more research in this area.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.