ArticleClinical & experimental metastasis2011
Two possible mechanisms of epithelial to mesenchymal transition in invasive ductal breast cancer.
Article in Clinical & experimental metastasis, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 23 citations in OpenAlex.
- SNAIL is induced by tamoxifen and leads to growth inhibition in invasive lobular breast carcinoma.Breast cancer research and treatment · 2019Article
- Cadherin-11 expression is upregulated in invasive human breast cancer.Oncology letters · 2016Article
- Three-Dimensional Breast Cancer Models Mimic Hallmarks of Size-Induced Tumor Progression.Cancer research · 2016Article
- Translating epithelial mesenchymal transition markers into the clinic: Novel insights from proteomics.EuPA open proteomics · 2016Article
- Implications of the Notch1-Snail/Slug-epithelial to mesenchymal transition axis for lymph node metastasis in infiltrating ductal carcinoma.The Kaohsiung journal of medical sciences · 2015Article
- The pan-inhibitor of Aurora kinases danusertib induces apoptosis and autophagy and suppresses epithelial-to-mesenchymal transition in human breast cancer cells.Drug design, development and therapy · 2015Article
- Correlation and prognostic value of SIRT1 and Notch1 signaling in breast cancer.Journal of experimental & clinical cancer research : CR · 2014Article
- Oncostatin-M promotes phenotypic changes associated with mesenchymal and stem cell-like differentiation in breast cancer.Oncogene · 2014Article
- Keratinocyte growth factor and thiazolidinediones and linolenic acid differentiate characterized mammary fat pad adipose stem cells isolated from prepubertal Korean black goat to epithelial and adipogenic lineage.In vitro cellular & developmental biology. Animal · 2014Article
- Lipocalin-2 is associated with a good prognosis and reversing epithelial-to-mesenchymal transition in pancreatic cancer.World journal of surgery · 2013Article
- TMA Navigator: Network inference, patient stratification and survival analysis with tissue microarray data.Nucleic acids research · 2013Article
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- Is upregulation of BCL2 a determinant of tumor development driven by inactivation of CDH1/E-cadherin?PloS one · 2013Article
- Dynamic transcription factor networks in epithelial-mesenchymal transition in breast cancer models.PloS one · 2013Article
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- The role and function of cadherins in the mammary gland.Breast cancer research : BCR · 2012Review
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- Breast cancer epithelial-to-mesenchymal transition: examining the functional consequences of plasticity.Breast cancer research : BCR · 2011Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epithelial to mesenchymal transition (EMT) occurs in embryogenesis and normal development. It has been predominantly described in vitro and in animal studies, but EMT is also implicated in the progression of many cancers with proposed roles in invasion, metastasis and resistance to treatment. It is closely associated with loss of epithelial-specific protein expression and up-regulation of mesenchymal proteins, but several pathways are implicated in its execution. We explored what are the expression patterns of EMT proteins in human breast cancer. We interrogated two independent cohorts enriched for high-grade, invasive, ductal breast cancers. We used quantitative immunofluorescence to study the expression of key EMT proteins. Statistical associations to define protein profiles were based on Pearson's correlations. E-cadherin down-regulation in breast cancer was associated with β-catenin down-regulation, but not with up-regulation of mesenchymal markers. While EMT-related transcription repressors were expressed in some breast cancers, their expression did not negatively correlate with E-cadherin. Instead, an additional EMT profile was identified, composing Snail and Slug. In conclusion, EMT occurs in human breast cancer in a manner distinct to that seen in vitro. Certain EMT events are uncoupled from E-cadherin down-regulation and may constitute a novel EMT profile, which warrants further exploration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.