ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2011
MGMT promoter gene methylation in pediatric glioblastoma: analysis using MS-MLPA.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Impact of tumor location and pathological discordance on survival of children with midline high-grade gliomas treated on Children's Cancer Group high-grade glioma study CCG-945.Journal of neuro-oncology · 2015Trial
- Clinical Outcomes and Prognostic Features of Diffuse Hemispheric Glioma, H3 G34-Mutant: An International Multi-institutional Study.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026Article
- Review
- Advanced Magnetic Resonance Imaging in Pediatric Glioblastomas.Frontiers in neurology · 2021Review
- Multiplexed methylation profiles of tumor suppressor genes and clinical outcome in oligodendroglial tumors.Cancer medicine · 2016Article
- MGMT methylation assessment in glioblastoma: MS-MLPA versus human methylation 450K beadchip array and immunohistochemistry.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2016Article
- Pediatric glioblastoma: a single institution experience.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016Article
- Molecular Biology in Pediatric High-Grade Glioma: Impact on Prognosis and Treatment.BioMed research international · 2015Review
- Article
- Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge.Nature reviews. Cancer · 2014Review
- Distinct genetic alterations in pediatric glioblastomas.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2012Article
- Impact of molecular biology studies on the understanding of brain tumors in childhood.Current oncology reports · 2012Article
- Use of the MLPA assay in the molecular diagnosis of gene copy number alterations in human genetic diseases.International journal of molecular sciences · 2012Review
- DNA methylation, histone modifications, and signal transduction pathways: a close relationship in malignant gliomas pathophysiology.Journal of signal transduction · 2012Article
- Systematic review of diffuse hemispheric glioma, H3 G34-mutant: Outcomes and associated clinical factors.Neuro-oncology advancesArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePromoter methylation of the O⁶-methylguanine-DNA-methyltransferase (MGMT) gene is widely recognized as an important predictive factor in the treatment of glioblastoma (GBM) patients with temozolomide. However, data regarding the methylation status of the MGMT promoter in pediatric GBM are yet to be elucidated.
methodsNineteen tissue samples of pediatric GBM were evaluated for the MGMT promoter methylation status using methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA). Methylation status was also evaluated using methylation-specific polymerase chain reaction (MSP) for 17 of the 19 patients. The correlation between MGMT promoter methylation and clinical outcome was assessed.
resultsThree of the 19 patients (16%) showed methylation of the MGMT promoter, according to MS-MLPA, as did 1 of the 17 (6%), according to MSP. The methylation status did not seem to have a definite effect on clinical outcome.
conclusionsPediatric GBMs rarely have methylated MGMT promoters. With a better clinical outcome and lower methylation rate than their adult counterparts, it may be suggested that, for pediatric GBM, MGMT promoter methylation does not play a significant role as a prognostic factor.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.