ArticleVirus genes2011
Sequence analysis of the Meq gene in the predominant Marek's disease virus strains isolated in China during 2006-2008.
Article in Virus genes, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 45 citations in OpenAlex.
- Virulence of Marek's disease virus in Japan is linked to polymorphisms in theThe Journal of general virology · 2026Article
- TheViruses · 2024Article
- Emerging Hypervirulent Marek's Disease Virus Variants Significantly Overcome Protection Conferred by Commercial Vaccines.Viruses · 2023Article
- Differences in Pathogenicity and Vaccine Resistance Discovered between Two Epidemic Strains of Marek's Disease Virus in China.Viruses · 2023Article
- Genetic characterization of a Marek's disease virus strain isolated in Japan.Virology journal · 2020Article
- Molecular epidemiology of Marek's disease virus in central Pennsylvania, USA.Virus evolution · 2019Article
- Characterization of a Gallid herpesvirus 2 strain with novel reticuloendotheliosis virus long terminal repeat inserts.Virus genes · 2017Article
- Sequence analysis of Meq oncogene among Indian isolates of Marek's disease herpesvirus.Meta gene · 2016Article
- Diversity of Meq gene from clinical Marek's disease virus infection in Saudi Arabia.Veterinary world · 2016Article
- Molecular and pathogenicity characterization of Gallid herpesvirus 2 newly isolated in China from 2009 to 2013.Virus genes · 2016Article
- Outbreak of Marek's disease in a vaccinated broiler breeding flock during its peak egg-laying period in China.BMC veterinary research · 2015Article
- Isolation and full-genome sequence of two reticuloendotheliosis virus strains from mixed infections with Marek's disease virus in China.Virus genes · 2015Article
- Molecular characteristics and evolutionary analysis of field Marek's disease virus prevalent in vaccinated chicken flocks in recent years in China.Virus genes · 2013Article
- Isolation and analysis of a very virulent Marek's disease virus strain in China.Virology journal · 2013Article
- Genome sequence determination and analysis of a Chinese virulent strain, LMS, of Gallid herpesvirus type 2.Virus genes · 2012Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The main aim of the present study were to investigate sequence diversity in the Meq gene of Marek's disease viruses (MDV) isolated in China and to determine the most prevalent MDV strains. The 19 MDV strains were isolated from dead or diseased chickens from different chicken farms in China during 2006-2008, and the Meq gene was sequenced from each of these strains. Sequence analysis showed that all of the isolates contained an open reading frame of 1020 nucleotides, which encoded a 339 amino acid peptide. Compared with reference MDV strains, 12 of the 19 MDV isolates possessed two amino acid substitutions, (T → A) at position 139 and (P → R) at position 176, one isolate shared sequence similarity with the attenuated strain CVI988, and five of the other six isolates exhibited one amino acid change (P → T) at position 177 or 176. The 19 MDV isolates shared between 99.0 and 100% nucleotide sequence homology, and between 97.7 and 100% amino acid sequence homology. The nucleotide and amino acid sequence identity between the 19 MDV isolates and the 25 reference MDV strains varied from 97.6 to 100% and 94.4 to 100%, respectively. Based on the phylogenetic relationships between Meq gene sequences, Chinese MDV isolates constituted a separate clade to MDV reference strains, demonstrating that a different genotype of MDV was prevalent in China between 2006 and 2008.
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