ArticleNeuroradiology2011
Tissue at risk in the deep middle cerebral artery territory is critical to stroke outcome.
Article in Neuroradiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Safety and efficacy of intravenous thrombolysis: a systematic review and meta-analysis of 93,057 minor stroke patients.BMC neurology · 2025Pooled it
- Trial
- Impact of eloquent motor cortex-tissue reperfusion beyond the traditional thrombolysis in cerebral infarction (TICI) scoring after thrombectomy.Journal of neurointerventional surgery · 2021Article
- Early Thrombectomy Protects the Internal Capsule in Patients With Proximal Middle Cerebral Artery Occlusion.Stroke · 2021Observational
- Non-human Primate Models to Explore the Adaptive Mechanisms After Stroke.Frontiers in systems neuroscience · 2021Review
- Metabolome of Cerebral Thrombi Reveals an Association between High Glycemia at Stroke Onset and Good Clinical Outcome.Metabolites · 2020Article
- Targeted Infarction of the Internal Capsule in the Rat Using Microstimulation Guidance.Stroke · 2019Article
- Aphasia outcome: the interactions between initial severity, lesion size and location.Journal of neurology · 2019Article
- Mechanical Thrombectomy in Ischemic Stroke Patients With Alberta Stroke Program Early Computed Tomography Score 0-5.Stroke · 2019Article
- Multivariate prediction of functional outcome using lesion topography characterized by acute diffusion tensor imaging.NeuroImage. Clinical · 2019Article
- Clinical and radiological factors associated with unfavorable outcome after intravenous thrombolysis in patients with mild ischemic stroke.BMC neurology · 2018Article
- Capsular stroke modeling based on somatotopic mapping of motor fibers.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Cerebral regions preserved by successful endovascular recanalization of acute M1 segment occlusions: a voxel based analysis.The British journal of radiology · 2017Article
- Nonhuman primate models of focal cerebral ischemia.Neural regeneration research · 2017Review
- Development and Characterization of a Macaque Model of Focal Internal Capsular Infarcts.PloS one · 2016Article
- Large deep white matter lesions may predict futile recanalization in endovascular therapy for acute ischemic stroke.Interventional neurology · 2015Article
- Presence of anterior temporal artery associates with good outcome in acute atherosclerotic M1-middle cerebral artery occlusion.Neuroradiology · 2014Article
- Tissue at risk in acute stroke patients treated beyond 8 h after symptom onset.Neuroradiology · 2013Article
- The relationship between cortical blood flow and sub-cortical white-matter health across the adult age span.PloS one · 2013Article
- Future trials of endovascular mechanical recanalisation therapy in acute ischemic stroke patients - a position paper endorsed by ESMINT and ESNR : part II: methodology of future trials.Neuroradiology · 2012Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe clinical efficacy of thrombolysis in stroke patients is explained by the increased rate of recanalization, which limits infarct growth. However, the efficacy could also be explained by the protection of specific sites of the brain. Here, we investigate where is this outcome-related tissue at risk using voxel-based analysis.
methodsWe included 68 acute stroke patients with middle cerebral artery (MCA) occlusion on the admission MRI performed within 6 h of symptoms onset (H6) and 16 controls. MCA recanalization was assessed using the magnetic resonance angiography performed at day 1 (D1). Apparent diffusion coefficient (ADC) changes were analyzed using a voxel-based method between patients vs. controls group at admission (H6) in non-recanalized vs. recanalized and in 3-month poor vs. good outcome patients at D1.
resultsComplete or partial MCA recanalization was observed in 52 of 68 patients. Good outcome at 3 months occurred in 40 patients (59%). In non-recanalized patients, ADC was decreased in the deep MCA and watershed arterial territory (the lenticular nucleus, internal capsule, and the overlying periventricular white matter). This decrease was not observed in recanalized patients at D1 or patients at H6. Fiber tracking suggested that the area is crossed by the cortico-spinal, cerebellar, and intra-hemispheric association tracts. Finally, this area almost co-localized with the area associated with poor outcome.
conclusionsA clinically relevant area of tissue at risk may occur in patients with MCA infarcts at the level of deep white matter fiber tracts. These findings suggest that neuroprotection research should be refocused on white matter.
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