ArticleImmunogenetics2012
Divergent human populations show extensive shared IGK rearrangements in peripheral blood B cells.
Article in Immunogenetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 45 citations in OpenAlex.
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- Rare, convergent antibodies targeting the stem helix broadly neutralize diverse betacoronaviruses.Cell host & microbe · 2023Article
- DNA cytosine deamination is associated with recurrent Somatic Copy Number Alterations in stomach adenocarcinoma.Frontiers in genetics · 2023Article
- A SARS-CoV-2 neutralizing antibody discovery by single cell sequencing and molecular modeling.Journal of biomedical research · 2022Article
- Population matched (pm) germline allelic variants of immunoglobulin (IG) loci: Relevance in infectious diseases and vaccination studies in human populations.Genes and immunity · 2021Article
- Distinct clonal evolution of B-cells in HIV controllers with neutralizing antibody breadth.eLife · 2021Article
- A single donor is sufficient to produce a highly functional in vitro antibody library.Communications biology · 2021Article
- Lower Somatic Mutation Levels in theEvidence-based complementary and alternative medicine : eCAM · 2021Article
- How repertoire data are changing antibody science.The Journal of biological chemistry · 2020Review
- VDJbase: an adaptive immune receptor genotype and haplotype database.Nucleic acids research · 2020Article
- OGRDB: a reference database of inferred immune receptor genes.Nucleic acids research · 2020Article
- Differential Expression of IgM and IgD Discriminates Two Subpopulations of Human Circulating IgMFrontiers in immunology · 2020Article
- The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen.Science translational medicine · 2018Article
- On being the right size: antibody repertoire formation in the mouse and human.Immunogenetics · 2018Review
- Evidence for Shaping of Light Chain Repertoire by Structural Selection.Frontiers in immunology · 2018Article
- Immunoglobulin Light Chain Gene Rearrangements, Receptor Editing and the Development of a Self-Tolerant Antibody Repertoire.Frontiers in immunology · 2018Review
- Senescent cells expose and secrete an oxidized form of membrane-bound vimentin as revealed by a natural polyreactive antibody.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Large-scale sequence and structural comparisons of human naive and antigen-experienced antibody repertoires.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak.Science (New York, N.Y.) · 2016Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have analysed the transcribed immunoglobulin kappa (IGK) repertoire of peripheral blood B cells from four individuals from two genetically distinct populations, Papua New Guinean and Australian, using high-throughput DNA sequencing. The depth of sequencing data for each individual averaged 5,548 high-quality IGK reads, and permitted genotyping of the inferred IGKV and IGKJ germline gene segments for each individual. All individuals were homozygous at each IGKJ locus and had highly similar inferred IGKV genotypes. Preferential gene usage was seen at both the IGKV and IGKJ loci, but only IGKV segment usage varied significantly between individuals. Despite the differences in IGKV gene utilisation, the rearranged IGK repertoires showed extensive identity at the amino acid level. Public rearrangements (those shared by two or more individuals) made up 60.2% of the total sequenced IGK rearrangements. The total diversity of IGK rearrangements of each individual was estimated to range from just 340 to 549 unique amino acid sequences. Thus, the repertoire of unique expressed IGK rearrangements is dramatically less than previous theoretical estimates of IGK diversity, and the majority of expressed IGK rearrangements are likely to be extensively shared in individual human beings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.