ArticleParasitology research2012
Anthelmintic effect of a methanol extract of leaves of Dregea volubilis on Paramphistomum explanatum.
Article in Parasitology research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Exploring the anthelmintic potential of some fabaceous plants: a comprehensive review.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2025Review
- Evaluation of in vitro anthelmintic activity of crude extract and synthesized green silver nanoparticles of the leaves ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2024Article
- Anthelmintic Activity of Saussurea costus (Falc.) Lipsch. Against Ascaridia galli, a Pathogenic Nematode in Poultry: In Vitro and In Vivo Studies.Acta parasitologica · 2024Article
- Octadecadienoate derivatives from Michelia champaca seed extract as potential larvicide and pupicide against Dengue vector Aedes albopictus.BMC research notes · 2023Article
- Article
- Biological Parameters for Evaluating the Toxic Potency of Petroleum Ether Extract of Wattakaka volubilis in Wistar Female Rats.Journal of pharmacopuncture · 2014Article
- In vitro and in vivo screening of anthelmintic activity of ginger and curcumin on Ascaridia galli.Parasitology research · 2013Article
- Screening of 42 medicinal plants for in vivo anthelmintic activity against Dactylogyrus intermedius (Monogenea) in goldfish (Carassius auratus).Parasitology research · 2012Article
- Anthelmintic effect of a methanol extract of Bombax malabaricum leaves on Paramphistomum explanatum.Parasitology research · 2012Article
- Tegumental Effects of Methanolic Extract ofIranian journal of parasitologyArticle
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dregea volubilis (family Asclepediaceae) is widely used as anthelmintic in traditional system of medicine in eastern and southern part of India. The aim of this study was to evaluate the anthelmintic activity of the methanol extract of D. volubilis leaves (MEDV) and to observe its effect through SEM study. Live parasites (trematode Paramphistomum explanatum) were collected from buffalo in 0.9% phosphate-buffered saline (PBS). It was incubated at 37 ± 1°C in media containing either no extract (control), the test drug, MEDV at four dose levels (10, 25, 50, and 100 mg/ml) or the standard drug, albendazole, at a dose of 10 mg/ml. The effectiveness of the extract was judged on the basis of the loss of spontaneous movement and/or complete destruction or death of the trematodes. After being removed from the experimental medium, trematodes were dipped in PBS at 37 ± 1°C and on gentle stimulation, the paralyzed parasite showed immobility. Death was confirmed when it completely lost its motility even when vigorously shaken or dipped in warm water (50°C). The trematodes, both drug treated and others, were further processed for SEM study using standard method. The anthelmintic activity was found with all the doses through paralysis and death of the organisms (p < 0.001). Maximum anthelmintic activity was found with a dose of 100 mg/ml. Minor damage was observed with both suckers, but severe distortion was found with tegumental surface of the treated trematodes. The present SEM-based study established the anthelmintic activity of MEDV.
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