ReviewJournal of mammary gland biology and neoplasia2011
Innate immune cells in breast cancer--from villains to heroes?
Review in Journal of mammary gland biology and neoplasia, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cross Cancer Genomic Investigation of Inflammation Pathway for Five Common Cancers: Lung, Ovary, Prostate, Breast, and Colorectal Cancer.Journal of the National Cancer Institute · 2015Pooled it
- Article
- Adeno-associated virus-9 reverses delayed gastric emptying of solids in diabetic mice.Neurogastroenterology and motility · 2023Article
- Review
- Targeting Innate Immunity in Breast Cancer Therapy: A Narrative Review.Frontiers in immunology · 2021Review
- The Use of Zebrafish Xenotransplant Assays to Analyze the Role of lncRNAs in Breast Cancer.Frontiers in oncology · 2021Review
- Anticancer Activity of Liquid Treated with Microwave Plasma-Generated Gas through Macrophage Activation.Oxidative medicine and cellular longevity · 2020Article
- [Research progress on nonspecific immune microenvironment in breast cancer].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2018Review
- Function of miR-146a-5p in Tumor Cells As a Regulatory Switch between Cell Death and Angiogenesis: Macrophage Therapy Revisited.Frontiers in immunology · 2017Article
- Higher circulating levels of chemokine CXCL10 in patients with breast cancer: Evaluation of the influences of tumor stage and chemokine gene polymorphism.Cancer biomarkers : section A of Disease markers · 2016Article
- Evaluation of the circulating levels of IL-12 and IL-33 in patients with breast cancer: influences of the tumor stages and cytokine gene polymorphisms.Iranian journal of basic medical sciences · 2015Article
- Il-6 signaling between ductal carcinoma in situ cells and carcinoma-associated fibroblasts mediates tumor cell growth and migration.BMC cancer · 2015Article
- Monocytes and macrophages, implications for breast cancer migration and stem cell-like activity and treatment.Oncotarget · 2015Article
- Higher circulating levels of chemokine CCL22 in patients with breast cancer: evaluation of the influences of tumor stage and chemokine gene polymorphism.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Hooking the big one: the potential of zebrafish xenotransplantation to reform cancer drug screening in the genomic era.Disease models & mechanisms · 2014Review
- Interactions of ion transporters and channels with cancer cell metabolism and the tumour microenvironment.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Matrix metalloproteinase 8 (collagenase 2) induces the expression of interleukins 6 and 8 in breast cancer cells.The Journal of biological chemistry · 2013Article
- Cell volume regulation in epithelial physiology and cancer.Frontiers in physiology · 2013Review
- Macrophage-tumor cell interactions regulate the function of nitric oxide.Frontiers in physiology · 2013Article
- Exosomes in Cancer Microenvironment and Beyond: have we Overlooked these Extracellular Messengers?Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The innate immune system ensures effective protection against foreign pathogens and plays important roles in tissue remodeling. There are many types of innate immune cells, including monocytes, macrophages, dendritic cells, and granulocytes. Interestingly, these cells accumulate in most solid tumors, including those of the breast. There, they play a tumor-promoting role through secretion of growth and angiogenic factors, as well as immunosuppressive molecules. This is in strong contrast to the tumor-suppressing effects that innate immune cells exert in vitro upon proper activation. Therapeutic approaches have been developed with the aim of achieving similar suppressive activities in vivo. However, multiple factors in the tumor microenvironment, many of which are immunosuppressive, represent a major obstacle to effective treatment. Here, we discuss the potential of combating breast cancer through activation of the innate immune system, including possible strategies to enhance the success of immunotherapy.
Indexed as
Identifiers
21789554What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.