ArticleHuman genetics2012
The impact of Converso Jews on the genomes of modern Latin Americans.
Article in Human genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- NAT2 global landscape: Genetic diversity and acetylation statuses from a systematic review.PloS one · 2023Pooled it
- BRCA1 c.68_69del as a founder variant in the Spanish Roma: prevalence and screening implications.European journal of human genetics : EJHG · 2026Article
- Sephardic origins revealed for rare skin disorder, recessive dystrophic epidermolysis bullosa, in individuals carrying the unique c.6527insC mutation.Journal of medical genetics · 2025Article
- Article
- Population-based screening of Uruguayan Ashkenazi Jews for recurrent BRCA1 and BRCA2 pathogenic sequence variants.Molecular genetics & genomic medicine · 2022Article
- Ancestral patterns of recessive dystrophic epidermolysis bullosa mutations in Hispanic populations suggest sephardic ancestry.American journal of medical genetics. Part A · 2021Article
- Genetic epidemiology of BRCA1- and BRCA2-associated cancer across Latin America.NPJ breast cancer · 2021Article
- Insights from the clinical phenotype of subjects with Laron syndrome in Ecuador.Reviews in endocrine & metabolic disorders · 2021Review
- Middle eastern genetic legacy in the paternal and maternal gene pools of Chuetas.Scientific reports · 2020Article
- Branding of subjects affected with genetic syndromes of severe short stature in developing countries.BMJ case reports · 2020Article
- Latin Americans show wide-spread Converso ancestry and imprint of local Native ancestry on physical appearance.Nature communications · 2018Article
- Mutational spectrum in a worldwide study of 29,700 families with BRCA1 or BRCA2 mutations.Human mutation · 2018Article
- The time and place of European admixture in Ashkenazi Jewish history.PLoS genetics · 2017Article
- Echoes from Sepharad: signatures on the maternal gene pool of crypto-Jewish descendants.European journal of human genetics : EJHG · 2015Article
- Recurrent BRCA1 and BRCA2 mutations in Mexican women with breast cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2015Article
- Portuguese crypto-Jews: the genetic heritage of a complex history.Frontiers in genetics · 2015Review
- Inference of historical migration rates via haplotype sharing.Bioinformatics (Oxford, England) · 2013Article
- The population genetics of the Jewish people.Human genetics · 2013Review
- Haplotype analysis of the 185delAG BRCA1 mutation in ethnically diverse populations.European journal of human genetics : EJHG · 2013Article
- Prevalence and type of BRCA mutations in Hispanics undergoing genetic cancer risk assessment in the southwestern United States: a report from the Clinical Cancer Genetics Community Research Network.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2013Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Modern day Latin America resulted from the encounter of Europeans with the indigenous peoples of the Americas in 1492, followed by waves of migration from Europe and Africa. As a result, the genomic structure of present day Latin Americans was determined both by the genetic structure of the founding populations and the numbers of migrants from these different populations. Here, we analyzed DNA collected from two well-established communities in Colorado (33 unrelated individuals) and Ecuador (20 unrelated individuals) with a measurable prevalence of the BRCA1 c.185delAG and the GHR c.E180 mutations, respectively, using Affymetrix Genome-wide Human SNP 6.0 arrays to identify their ancestry. These mutations are thought to have been brought to these communities by Sephardic Jewish progenitors. Principal component analysis and clustering methods were employed to determine the genome-wide patterns of continental ancestry within both populations using single nucleotide polymorphisms, complemented by determination of Y-chromosomal and mitochondrial DNA haplotypes. When examining the presumed European component of these two communities, we demonstrate enrichment for Sephardic Jewish ancestry not only for these mutations, but also for other segments as well. Although comparison of both groups to a reference Hispanic/Latino population of Mexicans demonstrated proximity and similarity to other modern day communities derived from a European and Native American two-way admixture, identity-by-descent and Y-chromosome mapping demonstrated signatures of Sephardim in both communities. These findings are consistent with historical accounts of Jewish migration from the realms that comprise modern Spain and Portugal during the Age of Discovery. More importantly, they provide a rationale for the occurrence of mutations typically associated with the Jewish Diaspora in Latin American communities.
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