ArticleClinics (Sao Paulo, Brazil)2011
Low-Intensity physical activity beneficially alters the ultrastructural renal morphology of spontaneously hypertensive rats.
Article in Clinics (Sao Paulo, Brazil), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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9 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Cardiovascular effects of exercise training in spontaneously hypertensive rats: A systematic review and meta-analysis.Physiological reports · 2026Pooled it
- Associations of accelerometer-derived physical activity with chronic kidney disease risk in a population with hypertension: a prospective cohort study.BMC nephrology · 2026Article
- Article
- The Role of Connexin 43 in Renal Disease: Insights from In Vivo Models of Experimental Nephropathy.International journal of molecular sciences · 2022Review
- Effect of free running wheel exercise on renal expression of parathyroid hormone receptor type 1 in spontaneously hypertensive rats.Physiological reports · 2018Article
- Anti-Renal Fibrotic Effect of Exercise Training in Hypertension.International journal of molecular sciences · 2018Article
- Contribution of mitochondrial function to exercise-induced attenuation of renal dysfunction in spontaneously hypertensive rats.Molecular and cellular biochemistry · 2015Article
- Exercise training improves cardiovascular autonomic activity and attenuates renal damage in spontaneously hypertensive rats.Journal of sports science & medicine · 2013Article
- Exercise and its interactions with various aspects of man and animal lives.Acta ortopedica brasileira · 2012Article
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5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
INTRODUCTION AND
objectiveKidney disorders can cause essential hypertension, which can subsequently cause renal disease. High blood pressure is also common among those with chronic kidney disease; moreover, it is a well-known risk factor for a more rapid progression to kidney failure. Because hypertension and kidney function are closely linked, the present study aimed to observe the beneficial effects of low-intensity physical activity on structural and ultrastructural renal morphology and blood pressure in normotensive and spontaneously hypertensive rats.
methodMale Wistar-Kyoto rats and spontaneously hypertensive rats were randomly allocated into four groups: sedentary or exercised Wistar-Kyoto and sedentary or exercised spontaneously hypertensive rats. The exercise lasted 20 weeks and consisted of treadmill training for 1 hour/day, 5 days/week.
resultsThe exercised, spontaneously hypertensive rats showed a significant blood pressure reduction of 26%. The body masses of the Wistar-Kyoto and spontaneously hypertensive strains were significantly different. There were improvements in some of the renal structures of the animals treated with physical activity: (i) the interdigitations of the proximal and distal convoluted tubules; (ii) the basal membrane of the proximal and distal convoluted tubules; and (iii) in the basal membrane, slit diaphragm and pedicels of the glomerular filtration barrier. The spontaneously hypertensive rats also showed a decreased expression of connexin-43.
conclusionPhysical exercise could be a therapeutic tool for improving kidney ultrastructure and, consequently, renal function in hypertensive individuals.
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