ArticleClinics (Sao Paulo, Brazil)2011
Chemical composition of the essential oil from kelussia odoratissima Mozaff. and the evaluation of its sedative and anxiolytic effects in mice.
Article in Clinics (Sao Paulo, Brazil), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 37 citations in OpenAlex.
- Chemical Investigations inMolecules (Basel, Switzerland) · 2023Article
- Evaluation of hepatic lipogenesis and antioxidant status of broiler chickens fed mountain celery.BMC veterinary research · 2018Article
- Article
- Antihypertensive and antioxidant effects of hydroalcoholic extract from the aerial parts of Kelussia odoratissima Mozaff. in dexamethasone-induced hypertensive rats.Advanced biomedical research · 2016Article
- Genotoxicity evaluation of hydroalcoholic and aqueous extracts ofAdvanced biomedical research · 2016Article
- Alleviation of Morphine Withdrawal Signs but Not Tolerance by the Essential Oil of Kelussia odoratissima Mozaff.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Isolation and Identification of Ferulic Acid From Aerial Parts of Kelussia odoratissima Mozaff.Jundishapur journal of natural pharmaceutical products · 2012Article
- Evaluation of anxiolytic and sedative effect of essential oil and hydroalcoholic extract of Ocimum basilicum L. and chemical composition of its essential oil.Research in pharmaceutical sciencesArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe present study aimed to evaluate the sedative and anxiolytic effects of the essential oils and hydroalcoholic extract of Kelussia odoratissima Mozaff. (K. odoratissima) in mice by utilizing an elevated plus maze. The chemical composition of its essential oil was also determined.
methodsThe hydroalcoholic extract or essential oil fraction from this plant were administered intraperitoneally to male mice at various doses 30 min before testing. The anxiolytic and sedative effects were determined by an elevated plus maze and locomotor activity tests, respectively.
resultsAccording to the results, none of the administered doses of hydroalcoholic extract or essential oil fraction of K. odoratissima changed the percentage of the time spent or number of entries into the open arms of the elevated plus maze. In contrast, the cumulative spontaneous locomotor activity of mice treated with the essential oil or hydroalcoholic extract was significantly decreased. Chemical analysis of the essential oil by Gas chromatography-mass spectromentry (GC-MS) showed that 3-butylidene-4,5-dihydrophthalide (85.9%) was the major component.
conclusionThese data confirm the sedative properties of K. odoratissima, yet there were no profound anxiolytic effects observed.
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