ArticleJournal of lipids2011
Lipid abnormalities and cardiometabolic risk in patients with overt and subclinical thyroid disease.
Article in Journal of lipids, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The trial behind it
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Who cites it
39 citing papers in PubMed.
- A comparative study on serum lipid levels in patients with thyroid dysfunction: a single-center experience in Ethiopia.BMC endocrine disorders · 2025Article
- Thyroid Stimulatory Activity ofNutrients · 2025Article
- The Effects of Anti-thyroid Drugs on Lipoproteins and Insulin Resistance in Graves' Disease: A Randomized Clinical Trial.Journal of lipid and atherosclerosis · 2024Article
- Conventional HDL Subclass Measurements Mask Thyroid Hormone-dependent Remodeling Activity Sites in Hypothyroid Individuals.Journal of the Endocrine Society · 2024Article
- Characteristics and Prevalence of Metabolic Syndrome Among Adult Filipinos with Hypothyroidism: A Cross-sectional Study.Journal of the ASEAN Federation of Endocrine Societies · 2024Article
- Hepatic Energy Metabolism under the Local Control of the Thyroid Hormone System.International journal of molecular sciences · 2023Review
- The Prevalence of Metabolic Syndrome among Adult Filipinos with Hypothyroidism: A Retrospective Cohort Study.Acta medica Philippina · 2023Article
- Cancer and Mortality Risks of Graves' Disease in South Korea Based on National Data from 2010 to 2019.Clinical epidemiology · 2023Article
- Dyslipidemia in South African patients with hypothyroidism.Journal of clinical & translational endocrinology · 2022Article
- The protective role of nutritional antioxidants against oxidative stress in thyroid disorders.Frontiers in endocrinology · 2022Review
- Serum Prooxidant-Antioxidant Balance and hs-CRP in Patients with Clinical and Subclinical Hypothyroidism.International journal of preventive medicine · 2022Article
- Efficacy evaluation of probiotics combined with prebiotics in patients with clinical hypothyroidism complicated with small intestinal bacterial overgrowth during the second trimester of pregnancy.Frontiers in cellular and infection microbiology · 2022Article
- Analysis of epidemiological association patterns of serum thyrotropin by combining random forests and Bayesian networks.PloS one · 2022Article
- The Relationship of Circulating Proprotein Convertase Subtilisin/Kexin Type 9 With TSH and Lipid Profile in Newly Diagnosed Patients With Subclinical and Overt Hypothyroidism.Clinical medicine insights. Endocrinology and diabetes · 2022Article
- Metabolic Changes after Radioiodine Correction of Grade 1 and Grade 2 Subclinical Hyperthyroidism.European thyroid journal · 2021Article
- Association of lipoproteins and thyroid hormones with cognitive dysfunction in patients with systemic lupus erythematosus.BMC rheumatology · 2021Article
- Lipidomic Perturbations in Cynomolgus Monkeys are Regulated by Thyroid Stimulating Hormone.Frontiers in molecular biosciences · 2021Article
- Sensitivity to Thyroid Hormone Indices Are Closely Associated With NAFLD.Frontiers in endocrinology · 2021Article
- Oxidative stress enhances the immune response to oxidatively modified catalase enzyme in patients with Graves' disease.Journal of clinical laboratory analysis · 2020Article
- Untreated adult GH deficiency is not associated with the development of metabolic risk factors: a long-term observational study.Journal of endocrinological investigation · 2020Observational
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dyslipidemia is a common finding in patients with thyroid disease, explained by the adverse effects of thyroid hormones in almost all steps of lipid metabolism. Not only overt but also subclinical hypo- and hyperthyroidism, through different mechanisms, are associated with lipid alterations, mainly concerning total and LDL cholesterol and less often HDL cholesterol, triglycerides, lipoprotein (a), apolipoprotein A1, and apolipoprotein B. In addition to quantitative, qualitative alterations of lipids have been also reported, including atherogenic and oxidized LDL and HDL particles. In thyroid disease, dyslipidemia coexists with various metabolic abnormalities and induce insulin resistance and oxidative stress via a vice-vicious cycle. The above associations in combination with the thyroid hormone induced hemodynamic alterations, might explain the increased risk of coronary artery disease, cerebral ischemia risk, and angina pectoris in older, and possibly ischemic stroke in younger patients with overt or subclinical hyperthyroidism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.