ArticlePloS one2011
Large scale comparison of innate responses to viral and bacterial pathogens in mouse and macaque.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- An Inflammatory Composite Score Predicts Mycobacterial Immune Reconstitution Inflammatory Syndrome in People with Advanced HIV: A Prospective International Cohort Study.The Journal of infectious diseases · 2021Observational
- HIV and the tuberculosis "set point": how HIV impairs alveolar macrophage responses to tuberculosis and sets the stage for progressive disease.Retrovirology · 2020Review
- Urinary markers of oxidative stress respond to infection and late-life in wild chimpanzees.PloS one · 2020Article
- KillingMicrobiology spectrum · 2017Review
- Apoptosis, Toll-like, RIG-I-like and NOD-like Receptors Are Pathways Jointly Induced by Diverse Respiratory Bacterial and Viral Pathogens.Frontiers in microbiology · 2017Article
- A Role for Neutrophils in Viral Respiratory Disease.Frontiers in immunology · 2017Review
- Differential proteomic analysis of respiratory samples from patients suffering from influenza.Virusdisease · 2016Article
- A Perspective on Implementing a Quantitative Systems Pharmacology Platform for Drug Discovery and the Advancement of Personalized Medicine.Journal of biomolecular screening · 2016Article
- The use of nonhuman primates in research on seasonal, pandemic and avian influenza, 1893-2014.Antiviral research · 2015Review
- cDREM: inferring dynamic combinatorial gene regulation.Journal of computational biology : a journal of computational molecular cell biology · 2015Article
- ModuleBlast: identifying activated sub-networks within and across species.Nucleic acids research · 2015Article
- Response of primary human airway epithelial cells to influenza infection: a quantitative proteomic study.Journal of proteome research · 2012Article
- Studying and modelling dynamic biological processes using time-series gene expression data.Nature reviews. Genetics · 2012Review
- Matching experiments across species using expression values and textual information.Bioinformatics (Oxford, England) · 2012Article
- The non-human primate model of tuberculosis.Journal of medical primatology · 2012Review
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Viral and bacterial infections of the lower respiratory tract are major causes of morbidity and mortality worldwide. Alveolar macrophages line the alveolar spaces and are the first cells of the immune system to respond to invading pathogens. To determine the similarities and differences between the responses of mice and macaques to invading pathogens we profiled alveolar macrophages from these species following infection with two viral (PR8 and Fuj/02 influenza A) and two bacterial (Mycobacterium tuberculosis and Francisella tularensis Schu S4) pathogens. Cells were collected at 6 time points following each infection and expression profiles were compared across and between species. Our analyses identified a core set of genes, activated in both species and across all pathogens that were predominantly part of the interferon response pathway. In addition, we identified similarities across species in the way innate immune cells respond to lethal versus non-lethal pathogens. On the other hand we also found several species and pathogen specific response patterns. These results provide new insights into mechanisms by which the innate immune system responds to, and interacts with, invading pathogens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.