ArticlePloS one2011
Ensemble place codes in hippocampus: CA1, CA3, and dentate gyrus place cells have multiple place fields in large environments.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed.
- Article
- Single-Field Evolution Rule Governs the Dynamics of Representational Drift in Mouse Hippocampal Dorsal CA1 Region.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Pre-existing and emergent cortical neuronal assembly sequences during learning.bioRxiv : the preprint server for biology · 2025Article
- Effective computations for hippocampal place cell phenomena in sparse untrained random networks.bioRxiv : the preprint server for biology · 2025Article
- Synaptic signatures of perinatal cannabinoids: A systematic review of rodent hippocampal synaptic plasticity, learning, and memory.Drug and alcohol dependence reports · 2025Review
- Article
- Time Makes Space: Emergence of Place Fields in Networks Encoding Temporally Continuous Sensory Experiences.bioRxiv : the preprint server for biology · 2025Article
- Memory processing by hippocampal adult-born neurons.Neurobiology of learning and memory · 2025Review
- Article
- Article
- Integration of rate and phase codes by hippocampal cell-assemblies supports flexible encoding of spatiotemporal context.Nature communications · 2024Article
- Remapping revisited: how the hippocampus represents different spaces.Nature reviews. Neuroscience · 2024Review
- Spontaneous Dynamics of Hippocampal Place Fields in a Model of Combinatorial Competition among Stable Inputs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Phencyclidine Disrupts Neural Coordination and Cognitive Control by Dysregulating Translation.Biological psychiatry global open science · 2024Article
- Grid codes vs. multi-scale, multi-field place codes for space.Frontiers in computational neuroscience · 2024Article
- Estimating neuronal firing density: A quantitative analysis of firing rate map algorithms.PLoS computational biology · 2023Article
- Article
- Interactions between rodent visual and spatial systems during navigation.Nature reviews. Neuroscience · 2023Review
- The medial entorhinal cortex is necessary for the stimulus control over hippocampal place fields by distal, but not proximal, landmarks.Hippocampus · 2023Article
- An entorhinal-like region in food-caching birds.Current biology : CB · 2023Article
6 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors.
Funding
Abstract
Previously we reported that the hippocampus place code must be an ensemble code because place cells in the CA1 region of hippocampus have multiple place fields in a more natural, larger-than-standard enclosure with stairs that permitted movements in 3-D. Here, we further investigated the nature of hippocampal place codes by characterizing the spatial firing properties of place cells in the CA1, CA3, and dentate gyrus (DG) hippocampal subdivisions as rats foraged in a standard 76-cm cylinder as well as a larger-than-standard box (1.8 m×1.4 m) that did not have stairs or any internal structure to permit movements in 3-D. The rats were trained to forage continuously for 1 hour using computer-controlled food delivery. We confirmed that most place cells have single place fields in the standard cylinder and that the positional firing pattern remapped between the cylinder and the large enclosure. Importantly, place cells in the CA1, CA3 and DG areas all characteristically had multiple place fields that were irregularly spaced, as we had reported previously for CA1. We conclude that multiple place fields are a fundamental characteristic of hippocampal place cells that simplifies to a single field in sufficiently small spaces. An ensemble place code is compatible with these observations, which contradict any dedicated coding scheme.
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