ArticlePloS one2011
A novel manganese efflux system, YebN, is required for virulence by Xanthomonas oryzae pv. oryzae.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 47 citations in OpenAlex.
- Article
- Manganese Transporter Proteins in Salmonella enterica serovar Typhimurium.Journal of microbiology (Seoul, Korea) · 2023Review
- Why is manganese so valuable to bacterial pathogens?Frontiers in cellular and infection microbiology · 2023Review
- MntP and YiiP Contribute to Manganese Efflux in Salmonella enterica Serovar Typhimurium under Conditions of Manganese Overload and Nitrosative Stress.Microbiology spectrum · 2022Article
- Manganese Utilization inFrontiers in cell and developmental biology · 2022Review
- Enterococcus faecalis Manganese Exporter MntE Alleviates Manganese Toxicity and Is Required for Mouse Gastrointestinal Colonization.Infection and immunity · 2020Article
- Bacterial manganese sensing and homeostasis.Current opinion in chemical biology · 2020Review
- Genome-Scale Metabolic Model ofFrontiers in genetics · 2020Article
- Biosynthesis of Amino Acids inMicroorganisms · 2019Article
- Local-to-global signal transduction at the core of a MnNature communications · 2019Article
- Manganese Detoxification by MntE Is Critical for Resistance to Oxidative Stress and Virulence ofmBio · 2019Article
- RaxM regulates the AvrXa21 (RaxX)-mediated immune response.Molecular plant pathology · 2018Article
- Structure-function analysis of manganese exporter proteins across bacteria.The Journal of biological chemistry · 2018Article
- The periplasmic binding protein NrtT affects xantham gum production and pathogenesis inFEBS open bio · 2017Article
- Metalloriboswitches: RNA-based inorganic ion sensors that regulate genes.The Journal of biological chemistry · 2017Review
- Identification and Characterization of a Putative Manganese Export Protein in Vibrio cholerae.Journal of bacteriology · 2016Article
- Discrete Responses to Limitation for Iron and Manganese in Agrobacterium tumefaciens: Influence on Attachment and Biofilm Formation.Journal of bacteriology · 2015Article
- Specificity of metal sensing: iron and manganese homeostasis in Bacillus subtilis.The Journal of biological chemistry · 2014Review
- Chemical interference with iron transport systems to suppress bacterial growth of Streptococcus pneumoniae.PloS one · 2014Article
- Structural and functional characterization of an orphan ATP-binding cassette ATPase involved in manganese utilization and tolerance in Leptospira spp.Journal of bacteriology · 2013Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Manganese ions (Mn(2+)) play a crucial role in virulence and protection against oxidative stress in bacterial pathogens. Such pathogens appear to have evolved complex mechanisms for regulating Mn(2+) uptake and efflux. Despite numerous studies on Mn(2+) uptake, however, only one efflux system has been identified to date. Here, we report on a novel Mn(2+) export system, YebN, in Xanthomonas oryzae pv. oryzae (Xoo), the causative agent of bacterial leaf blight. Compared with wild-type PXO99, the yebN mutant was highly sensitive to Mn(2+) and accumulated high concentrations of intracellular manganese. In addition, we found that expression of yebN was positively regulated by Mn(2+) and the Mn(2+)-dependent transcription regulator, MntR. Interestingly, the yebN mutant was more tolerant to methyl viologen and H(2)O(2) in low Mn(2+) medium than PXO99, but more sensitive in high Mn(2+) medium, implying that YebN plays an important role in Mn(2+) homoeostasis and detoxification of reactive oxygen species (ROS). Notably, deletion of yebN rendered Xoo sensitive to hypo-osmotic shock, suggesting that YebN may protect against such stress. That mutation of yebN substantially reduced the Xoo growth rate and lesion formation in rice implies that YebN could be involved in Xoo fitness in host. Although YebN has two DUF204 domains, it lacks homology to any known metal transporter. Hence, this is the first report of a novel metal export system that plays essential roles in hypo-osmotic and oxidative stress, and virulence. Our results lay the foundations for elucidating the complex and fascinating relationship between metal homeostasis and host-pathogen interactions.
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