ArticlePloS one2011
Biphasic oxidation of oxy-hemoglobin in bloodstains.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 76 citations in OpenAlex.
- Spotlight on Endocannabinoids in Healthy Individuals Using Volumetric Absorptive Microsampling Combined with LC-MS/MS Analysis.ACS omega · 2025Article
- Influence of anticoagulant on the spectroscopic analysis of drying bovine blood pools.Journal of forensic sciences · 2025Article
- Short and Long Time Bloodstains Age Determination by Colorimetric Analysis: A Pilot Study.Molecules (Basel, Switzerland) · 2021Article
- Comparison of photoacoustic imaging and histopathological examination in determining the dimensions of 52 human melanomas and neviBiomedical optics express · 2021Article
- Hyperspectral Imaging for Bloodstain Identification.Sensors (Basel, Switzerland) · 2021Article
- The use of dried blood spots for characterizing children's exposure to organic environmental chemicals.Environmental research · 2021Review
- Untargeted adductomics of Cys34 modifications to human serum albumin in newborn dried blood spots.Analytical and bioanalytical chemistry · 2019Article
- Estimation of the age of human bloodstains under the simulated indoor and outdoor crime scene conditions by ATR-FTIR spectroscopy.Scientific reports · 2017Article
- NIR Raman spectra of whole human blood: effects of laser-induced and in vitro hemoglobin denaturation.Analytical and bioanalytical chemistry · 2014Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn forensic science, age determination of bloodstains can be crucial in reconstructing crimes. Upon exiting the body, bloodstains transit from bright red to dark brown, which is attributed to oxidation of oxy-hemoglobin (HbO(2)) to met-hemoglobin (met-Hb) and hemichrome (HC). The fractions of HbO(2), met-Hb and HC in a bloodstain can be used for age determination of bloodstains. In this study, we further analyze the conversion of HbO(2) to met-Hb and HC, and determine the effect of temperature and humidity on the conversion rates. METHODOLOGY: The fractions of HbO(2), met-Hb and HC in a bloodstain, as determined by quantitative analysis of optical reflectance spectra (450-800 nm), were measured as function of age, temperature and humidity. Additionally, Optical Coherence Tomography around 1300 nm was used to confirm quantitative spectral analysis approach.
conclusionsThe oxidation rate of HbO(2) in bloodstains is biphasic. At first, the oxidation of HbO(2) is rapid, but slows down after a few hours. These oxidation rates are strongly temperature dependent. However, the oxidation of HbO(2) seems to be independent of humidity, whereas the transition of met-Hb into HC strongly depends on humidity. Knowledge of these decay rates is indispensable for translating laboratory results into forensic practice, and to enable bloodstain age determination on the crime scene.
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