ArticlePloS one2011
Milk lacking α-casein leads to permanent reduction in body size in mice.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Trichothecene mycotoxin-induced ribotoxic stress activates histone gene transcription.Archives of toxicology · 2026Article
- Biotechnology Approaches to Dairy Alternatives Through Precision Fermentation and Cellular Agriculture.Food science of animal resources · 2025Review
- Maternal α-casein deficiency extends the lifespan of offspring and programmes their body composition.GeroScience · 2025Article
- Characterization of the colostrum proteome of primiparous Holstein cows and its association with colostrum immunoglobulin G concentrations.Journal of animal science and biotechnology · 2025Article
- Caseins: Versatility of Their Micellar Organization in Relation to the Functional and Nutritional Properties of Milk.Molecules (Basel, Switzerland) · 2023Review
- Obesogenic diet in mice compromises maternal metabolic physiology and lactation ability leading to reductions in neonatal viability.Acta physiologica (Oxford, England) · 2022Article
- Evaluation of the α-casein (CSN1S1) locus as a potential target for a site-specific transgene integration.Scientific reports · 2022Article
- Antibody cross-reactivity between casein and myelin-associated glycoprotein results in central nervous system demyelination.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Recent advances in understanding adverse effects associated with drugs targeting the serotonin receptor, 5-HT GPCR.Frontiers in global women's health · 2022Review
- Review: Genetic and protein variants of milk caseins in goats.Frontiers in genetics · 2022Review
- Longitudinal Changes in the Concentration of Major Human Milk Proteins in the First Six Months of Lactation and Their Effects on Infant Growth.Nutrients · 2021Article
- Epithelial Xbp1 is required for cellular proliferation and differentiation during mammary gland development.Molecular and cellular biology · 2015Article
- A milk protein, casein, as a proliferation promoting factor in prostate cancer cells.The world journal of men's health · 2014Article
- A novel highly divergent protein family identified from a viviparous insect by RNA-seq analysis: a potential target for tsetse fly-specific abortifacients.PLoS genetics · 2014Article
- The membrane-associated form of α(s1)-casein interacts with cholesterol-rich detergent-resistant microdomains.PloS one · 2014Article
- Targeted microRNA expression in dairy cattle directs production of β-lactoglobulin-free, high-casein milk.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
The major physiological function of milk is the transport of amino acids, carbohydrates, lipids and minerals to mammalian offspring. Caseins, the major milk proteins, are secreted in the form of a micelle consisting of protein and calcium-phosphate.We have analysed the role of the milk protein α-casein by inactivating the corresponding gene in mice. Absence of α-casein protein significantly curtails secretion of other milk proteins and calcium-phosphate, suggesting a role for α-casein in the establishment of casein micelles. In contrast, secretion of albumin, which is not synthesized in the mammary epithelium, into milk is not reduced. The absence of α-casein also significantly inhibits transcription of the other casein genes. α-Casein deficiency severely delays pup growth during lactation and results in a life-long body size reduction compared to control animals, but has only transient effects on physical and behavioural development of the pups. The data support a critical role for α-casein in casein micelle assembly. The results also confirm lactation as a critical window of metabolic programming and suggest milk protein concentration as a decisive factor in determining adult body weight.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.