ReviewNature reviews. Endocrinology2011
The role of homeodomain transcription factors in heritable pituitary disease.
Review in Nature reviews. Endocrinology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 54 citations in OpenAlex.
- Analysis ofJournal of clinical medicine · 2022Article
- Comprehensive Identification of Pathogenic Gene Variants in Patients With Neuroendocrine Disorders.The Journal of clinical endocrinology and metabolism · 2021Article
- Single-cell transcriptomics identifies divergent developmental lineage trajectories during human pituitary development.Nature communications · 2020Article
- The transcription factor PITX1 drives astrocyte differentiation by regulating the SOX9 gene.The Journal of biological chemistry · 2020Article
- Congenital pituitary hypoplasia model demonstrates hypothalamic OTX2 regulation of pituitary progenitor cells.The Journal of clinical investigation · 2020Article
- Stem Cells, Self-Renewal, and Lineage Commitment in the Endocrine System.Frontiers in endocrinology · 2019Review
- The origins of the circumventricular organs.Journal of anatomy · 2018Review
- Two novel LHX3 mutations in patients with combined pituitary hormone deficiency including cervical rigidity and sensorineural hearing loss.BMC endocrine disorders · 2017Article
- Transcription factor 7-like 1 is involved in hypothalamo-pituitary axis development in mice and humans.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Genetic regulation of murine pituitary development.Journal of molecular endocrinology · 2015Review
- Required enhancer-matrin-3 network interactions for a homeodomain transcription program.Nature · 2014Article
- Notch signaling in postnatal pituitary expansion: proliferation, progenitors, and cell specification.Molecular endocrinology (Baltimore, Md.) · 2014Article
- Article
- Transcriptome profiling identifies differentially expressed genes in postnatal developing pituitary gland of miniature pig.DNA research : an international journal for rapid publication of reports on genes and genomes · 2014Article
- Cell-specific actions of a human LHX3 gene enhancer during pituitary and spinal cord development.Molecular endocrinology (Baltimore, Md.) · 2013Article
- Isolated prolactin deficiency associated with serum autoantibodies against prolactin-secreting cells.The Journal of clinical endocrinology and metabolism · 2013Article
- Molecular and Clinical Findings in Patients with LHX4 and OTX2 Mutations.Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2013Article
- Height matters-from monogenic disorders to normal variation.Nature reviews. Endocrinology · 2013Review
- Developmental analysis and influence of genetic background on the Lhx3 W227ter mouse model of combined pituitary hormone deficiency disease.Endocrinology · 2013Article
- LHX3 interacts with inhibitor of histone acetyltransferase complex subunits LANP and TAF-1β to modulate pituitary gene regulation.PloS one · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The anterior pituitary gland secretes hormones that regulate developmental and physiological processes, including growth, the stress response, metabolic status, reproduction and lactation. During embryogenesis, cellular determination and differentiation events establish specialized hormone-secreting cell types within the anterior pituitary gland. These developmental decisions are mediated in part by the actions of a cascade of transcription factors, many of which belong to the homeodomain class of DNA-binding proteins. The discovery of some of these regulatory proteins has facilitated genetic analyses of patients with hormone deficiencies. The findings of these studies reveal that congenital defects-ranging from isolated hormone deficiencies to combined pituitary hormone deficiency syndromes-are sometimes associated with mutations in the genes encoding pituitary-acting developmental transcription factors. The phenotypes of affected individuals and animal models have together provided useful insights into the biology of these transcription factors and have suggested new hypotheses for testing in the basic science laboratory. Here, we summarize the gene regulatory pathways that control anterior pituitary development, with emphasis on the role of the homeodomain transcription factors in normal pituitary organogenesis and heritable pituitary disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.