ArticleJournal of occupational and environmental medicine2011
Longitudinal changes in bone lead levels: the VA Normative Aging Study.
Article in Journal of occupational and environmental medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Relationship between lead exposure and different types of hypertension: systematic review and dose-response meta-analysis.Frontiers in public health · 2025Pooled it
- The Burdens of Idiopathic Developmental Intellectual Disability Attributable to Lead Exposure from 1990 to 2023 and a Projection to 2050 in the USA: Findings from the Global Burden of Disease Study 2023.Healthcare (Basel, Switzerland) · 2026Article
- Bone lead variability in bone repository skeletal samples measured with portable x-ray fluorescence.The Science of the total environment · 2023Article
- Blood DNA methylation biomarkers of cumulative lead exposure in adults.Journal of exposure science & environmental epidemiology · 2021Article
- Review
- DNA Methylation-Based Biomarkers of Environmental Exposures for Human Population Studies.Current environmental health reports · 2020Review
- Article
- Neurotoxicity of low-level lead exposure: History, mechanisms of action, and behavioral effects in humans and preclinical models.Neurotoxicology · 2019Review
- Looking Backward: Long-Term Lead Exposure and Risk of Glaucoma.Environmental health perspectives · 2019Article
- Comparison of bone lead measured via portable x-ray fluorescence across and within bones.Environmental research · 2019Article
- Dietary patterns, bone lead and incident coronary heart disease among middle-aged to elderly men.Environmental research · 2019Article
- Bone Lead Levels and Risk of Incident Primary Open-Angle Glaucoma: The VA Normative Aging Study.Environmental health perspectives · 2018Article
- Urinary Lead Concentration Is an Independent Predictor of Cancer Mortality in the U.S. General Population.Frontiers in oncology · 2018Article
- Hearing loss, lead (Pb) exposure, and noise: a sound approach to ototoxicity exploration.Journal of toxicology and environmental health. Part B, Critical reviews · 2018Review
- Associations of cumulative Pb exposure and longitudinal changes in Mini-Mental Status Exam scores, global cognition and domains of cognition: The VA Normative Aging Study.Environmental research · 2017Article
- APOE ε4 allele modifies the association of lead exposure with age-related cognitive decline in older individuals.Environmental research · 2016Article
- Effects of Ambient Air Pollution Exposure on Olfaction: A Review.Environmental health perspectives · 2016Review
- Dose-Response Relationship between Cumulative Occupational Lead Exposure and the Associated Health Damages: A 20-Year Cohort Study of a Smelter in China.International journal of environmental research and public health · 2016Article
- Lead-Related Genetic Loci, Cumulative Lead Exposure and Incident Coronary Heart Disease: The Normative Aging Study.PloS one · 2016Article
- Biased Exposure-Health Effect Estimates from Selection in Cohort Studies: Are Environmental Studies at Particular Risk?Environmental health perspectives · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
objectiveBone lead is a cumulative measure of lead exposure that can also be remobilized. We examined repeated measures of bone lead over 11 years to characterize long-term changes and identify predictors of tibia and patella lead stores in an elderly male population.
methodsLead was measured every 3 to 5 years by k-x-ray fluorescence and mixed-effect models with random effects were used to evaluate change over time.
resultsA total of 554 participants provided up to four bone lead measurements. Final models predicted a -1.4% annual decline (95% CI: -2.2 to -0.7) for tibia lead and piecewise linear model for patella with an initial decline of 5.1% per year (95% CI: -6.2 to -3.9) during the first 4.6 years but no significant change thereafter (-0.4% [95% CI: -2.4 to 1.7]).
conclusionsThese results suggest that bone lead half-life may be longer than previously reported.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.