ArticleHypertension (Dallas, Tex. : 1979)2011
Association of sodium and potassium intake with left ventricular mass: coronary artery risk development in young adults.
Article in Hypertension (Dallas, Tex. : 1979), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Genome-Wide Association Meta-Analysis of Individuals of European Ancestry Identifies Suggestive Loci for Sodium Intake, Potassium Intake, and Their Ratio Measured from 24-Hour or Half-Day Urine Samples.The Journal of nutrition · 2020Pooled it
- Hydrochlorothiazide vs chlorthalidone, indapamide, and potassium-sparing/hydrochlorothiazide diuretics for reducing left ventricular hypertrophy: A systematic review and meta-analysis.Journal of clinical hypertension (Greenwich, Conn.) · 2018Pooled it
- Cardiovascular effects of dietary salt intake in aged healthy cats: a 2-year prospective randomized, blinded, and controlled study.PloS one · 2014Trial
- Association of triglyceride glucose-body mass index and left ventricular hypertrophy in patients with IgA nephropathy: a retrospective study.European journal of medical research · 2024Article
- Spot urinary sodium-to-potassium ratio is associated with blood pressure levels in healthy adolescents: the Wakayama Study.Journal of human hypertension · 2024Article
- New Insights on the Role of Marinobufagenin from Bench to Bedside in Cardiovascular and Kidney Diseases.International journal of molecular sciences · 2023Review
- Urinary sodium excretion and the risk of CVD: a community-based cohort study in Taiwan.The British journal of nutrition · 2022Article
- Dietary sodium and health: How much is too much for those with orthostatic disorders?Autonomic neuroscience : basic & clinical · 2022Review
- 24-hour sodium and potassium excretion in the Americas: a systematic review and meta-analysis.Revista panamericana de salud publica = Pan American journal of public health · 2022Review
- Article
- Effect of Salt Content Reduction on Food Processing Technology.Foods (Basel, Switzerland) · 2021Review
- Urinary sodium-to-potassium ratio associates with hypertension and current disease activity in patients with rheumatoid arthritis: a cross-sectional study.Arthritis research & therapy · 2021Article
- Mechanisms of Dietary Sodium-Induced Impairments in Endothelial Function and Potential Countermeasures.Nutrients · 2021Review
- Association of Urinary Sodium Excretion and Left Ventricular Hypertrophy in People With Type 2 Diabetes Mellitus: A Cross-Sectional Study.Frontiers in endocrinology · 2021Article
- Left Ventricular Mass Reduction by a Low-Sodium Diet in Treated Hypertensive Patients.Nutrients · 2020Article
- Lithium in Portuguese Bottled Natural Mineral Waters-Potential for Health Benefits?International journal of environmental research and public health · 2020Article
- A Contemporary Approach to Hypertensive Cardiomyopathy: Reversing Left Ventricular Hypertrophy.Current hypertension reports · 2020Review
- Comparison of 24-h Diet Records, 24-h Urine, and Duplicate Diets for Estimating Dietary Intakes of Potassium, Sodium, and Iodine in Children.Nutrients · 2019Article
- Association of the spot urine sodium-to-potassium ratio with blood pressure is independent of urinary Na and K levels: The Nagahama study.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Article
- The role of sodium in modulating immune cell function.Nature reviews. Nephrology · 2019Review
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6 authors.
Funding
Abstract
High salt intake may affect left ventricular mass (LVM). We hypothesized that urinary sodium (UNa) and sodium/potassium ratio (UNa/K) are associated with LVM in a predominantly normotensive cohort of young adults. The Coronary Artery Risk Development in Young Adults (CARDIA) Study is a multicenter cohort of black and white men and women aged 30±3.6 years at the time of baseline echocardiographic examination (1990-1991). 2D guided M-mode LVM indexed to body size (grams per meter(2.7)) was calculated, and UNa and potassium excretion assessed (average of three 24-hour urinary samples, n=1042). Linear and logistic regression analysis was used. Participants were 57% women and 55% black. Only 4% were hypertensive. UNa, urinary potassium, and UNa/K ratios were (mean±SD) 175.6±131.0, 56.4±46.3, and 3.4±1.4 mmol/24 h, respectively. Participants in the highest versus the lowest UNa excretion quartile had the greatest LVM (37.5 versus 34.0 g/m(2.7); P<0.001). Adjusted for age, sex, education, and race, LVM averaged 0.945 g/m(2.7) higher per SD of UNa/K (P=0.001). The relationship between UNa/K and LVM persisted among 399 participants with repeat echocardiographic measures 5 years later. In logistic regression analysis adjusted for age, sex, education, and race, each SD higher baseline UNa/K was associated with 23% and 38% greater chances of being in the highest quartile of LVM at baseline (odds ratio: 1.23; P=0.005) and 5 years later (odds ratio: 1.38; P=0.02). A higher sodium/potassium excretion ratio is significantly related to cardiac structure, even among healthy young adults.
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