ArticleDiabetes2011
Does genetic ancestry explain higher values of glycated hemoglobin in African Americans?
Article in Diabetes, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Development of type 2 diabetes mellitus in people with intermediate hyperglycaemia.The Cochrane database of systematic reviews · 2018Pooled it
- Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.PLoS medicine · 2017Pooled it
- Effect of ethnicity on HbA1c levels in individuals without diabetes: Systematic review and meta-analysis.PloS one · 2017Pooled it
- Genetic European Ancestry and Incident Diabetes in Black Individuals: Insights From the SPRINT Trial.Circulation. Genomic and precision medicine · 2022Trial
- HbA1c as a predictor of diabetes and as an outcome in the diabetes prevention program: a randomized clinical trial.Diabetes care · 2015Trial
- Misuse of Race in the Interpretation of HbAAnnals of internal medicine · 2025Article
- Racial and ethnic differences in circulating N-terminal pro-brain-type natriuretic peptide (NT-proBNP) in US adults.American journal of preventive cardiology · 2023Article
- HbAPreventing chronic disease · 2021Article
- Sickle Cell Trait, European Ancestry, and Longitudinal Tracking of HbADiabetes care · 2019Article
- Genetic Ancestry Markers and Difference in A1c Between African American and White in the Diabetes Prevention Program.The Journal of clinical endocrinology and metabolism · 2019Article
- Are There Clinical Implications of Racial Differences in HbA1c? A Difference, to Be a Difference, Must Make a Difference.Diabetes care · 2016Article
- Article
- Novel Risk Factors for Type 2 Diabetes in African-Americans.Current diabetes reports · 2015Review
- Racial differences in circulating natriuretic peptide levels: the atherosclerosis risk in communities study.Journal of the American Heart Association · 2015Article
- The contribution of biogeographical ancestry and socioeconomic status to racial/ethnic disparities in type 2 diabetes mellitus: results from the Boston Area Community Health Survey.Annals of epidemiology · 2014Article
- Association of African genetic ancestry with fasting glucose and HbA1c levels in non-diabetic individuals: the Boston Area Community Health (BACH) Prediabetes Study.Diabetologia · 2014Article
- Differing effects of metformin on glycemic control by race-ethnicity.The Journal of clinical endocrinology and metabolism · 2014Article
- High prevalence of diabetes and intermediate hyperglycemia - The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).Diabetology & metabolic syndrome · 2014Article
- Race/ethnicity disparities in dysglycemia among U.S. women of childbearing age found mainly in the nonoverweight/nonobese.Diabetes care · 2013Article
- Glucose-independent ethnic differences in HbA1c in people without known diabetes.Diabetes care · 2013Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveGlycated hemoglobin (HbA(1c)) values are higher in African Americans than whites, raising the question of whether classification of diabetes status by HbA(1c) should differ for African Americans. We investigated the relative contribution of genetic ancestry and nongenetic factors to HbA(1c) values and the effect of genetic ancestry on diabetes classification by HbA(1c) in African Americans. RESEARCH DESIGN AND
methodsWe performed a cross-sectional analysis of data from the community-based Atherosclerosis Risk in Communities (ARIC) Study. We estimated percentage of European genetic ancestry (PEA) for each of the 2,294 African Americans without known diabetes using 1,350 ancestry-informative markers. HbA(1c) was measured from whole-blood samples and categorized using American Diabetes Association diagnostic cut points (<5.7, 5.7-6.4, and ≥6.5%).
resultsPEA was inversely correlated with HbA(1c) (adjusted r = -0.07; P < 0.001) but explained <1% of its variance. Age and socioeconomic and metabolic factors, including fasting glucose, explained 13.8% of HbA(1c) variability. Eleven percent of participants were classified as having diabetes; adjustment for fasting glucose decreased this to 4.4%. Additional adjustment for PEA did not significantly reclassify diabetes status (net reclassification index = 0.034; P = 0.94) nor did further adjustment for demographic, socioeconomic, and metabolic risk factors.
conclusionsThe relative contribution of demographic and metabolic factors far outweighs the contribution of genetic ancestry to HbA(1c) values in African Americans. Moreover, the impact of adjusting for genetic ancestry when classifying diabetes by HbA(1c) is minimal after taking into account fasting glucose levels, thus supporting the use of currently recommended HbA(1c) categories for diagnosis of diabetes in African Americans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.