ArticleProceedings of the National Academy of Sciences of the United States of America2011
High nitrogen insensitive 9 (HNI9)-mediated systemic repression of root NO3- uptake is associated with changes in histone methylation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.
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Who cites it
60 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Primary nitrate responses mediated by calcium signalling and diverse protein phosphorylation.Journal of experimental botany · 2020Pooled it
- Long-Distance Trafficking of Mineral Elements From Soil-to-Seed Under Climate Change Impacts Crop Nutritional Quality.Plant, cell & environment · 2026Review
- The transcription elongation factor IWS1 promotes thermomorphogenesis by integrating the brassinosteroid and gibberellin pathways in Arabidopsis.Plant communications · 2026Article
- Uncovering the early and conserved molecular mechanisms of root nitrogen foraging in model and crops.BMC genomics · 2026Article
- Interacting MeZFP29 and MebZIPW regulates MeNRT2.2 from cassava responding to nitrate signaling.Plant cell reports · 2025Article
- Mixed Ammonium-Nitrate Nutrition Regulates Enzymes, Gene Expression, and Metabolic Pathways to Improve Nitrogen Uptake, Partitioning, and Utilization Efficiency in Rice.Plants (Basel, Switzerland) · 2025Article
- Transcriptome and metabolism study reveals impact of nitrogen fertilizer on triticale.Protoplasma · 2025Article
- Functional analyses of the NRT2 family of nitrate transporters inFrontiers in plant science · 2024Review
- Epigenetic modifications regulate cultivar-specific root development and metabolic adaptation to nitrogen availability in wheat.Nature communications · 2023Article
- Organ-specific characteristics govern the relationship between histone code dynamics and transcriptional reprogramming during nitrogen response in tomato.Communications biology · 2023Article
- Finding Balance in Adversity: Nitrate Signaling as the Key to Plant Growth, Resilience, and Stress Response.International journal of molecular sciences · 2023Review
- Epigenetic Regulation of Nitrogen Signaling and Adaptation in Plants.Plants (Basel, Switzerland) · 2023Review
- CG hypermethylation of theHorticulture research · 2023Article
- Histone chaperone NUCLEOSOME ASSEMBLY PROTEIN 1 proteins affect plant growth under nitrogen deficient conditions inPlant biotechnology (Tokyo, Japan) · 2023Article
- Article
- Control of the rhizobium-legume symbiosis by the plant nitrogen demand is tightly integrated at the whole plant level and requires inter-organ systemic signaling.Frontiers in plant science · 2023Review
- Comprehensive Survey of ChIP-Seq Datasets to Identify Candidate Iron Homeostasis Genes Regulated by Chromatin Modifications.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Positive selection and heat-response transcriptomes reveal adaptive features of the Brassicaceae desert model, Anastatica hierochuntica.The New phytologist · 2022Article
- Genome-wide investigation of histone acetyltransferase gene family and its responses to biotic and abiotic stress in foxtail millet (Setaria italica [L.] P. Beauv).BMC plant biology · 2022Article
- Mix-and-match: an improved, fast and accessible protocol for hypocotyl micrografting of Arabidopsis seedlings with systemic ACC responses as a case study.Plant methods · 2022Article
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Authors and funding
11 authors.
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Abstract
In plants, root nitrate uptake systems are under systemic feedback repression by the N satiety of the whole organism, thus adjusting the N acquisition capacity to the N demand for growth; however, the underlying molecular mechanisms are largely unknown. We previously isolated the Arabidopsis high nitrogen-insensitive 9-1 (hni9-1) mutant, impaired in the systemic feedback repression of the root nitrate transporter NRT2.1 by high N supply. Here, we show that HNI9 encodes Arabidopsis INTERACT WITH SPT6 (AtIWS1), an evolutionary conserved component of the RNA polymerase II complex. HNI9/AtIWS1 acts in roots to repress NRT2.1 transcription in response to high N supply. At a genomic level, HNI9/AtIWS1 is shown to play a broader role in N signaling by regulating several hundred N-responsive genes in roots. Repression of NRT2.1 transcription by high N supply is associated with an HNI9/AtIWS1-dependent increase in histone H3 lysine 27 trimethylation at the NRT2.1 locus. Our findings highlight the hypothesis that posttranslational chromatin modifications control nutrient acquisition in plants.
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