ArticleProceedings of the National Academy of Sciences of the United States of America2011
Iron-containing urease in a pathogenic bacterium.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 78 citations in OpenAlex.
- Photocontrolled Release of Urea Enables the Detection of Urea-Urease Intermediates by Cryo-FTIR.Angewandte Chemie (International ed. in English) · 2025Article
- Unveiling the role of microbial rease in ureolysis-induced calcium carbonate precipitation, Its mechanistic insights, and emerging applications.World journal of microbiology & biotechnology · 2025Review
- Nature of the Reactive Biferric Peroxy Intermediate P' in the Arylamine Oxygenases and Related Binuclear Fe Enzymes.Journal of the American Chemical Society · 2025Article
- An ancient ecospecies of Helicobacter pylori.Nature · 2024Article
- Biomineralization in Cave Bacteria-Popcorn and Soda Straw Crystal Formations, Morphologies, and Potential Metabolic Pathways.Frontiers in microbiology · 2022Article
- Iron-Containing Ureases.Coordination chemistry reviews · 2021Article
- Breast milk urea as a nitrogen source for urease positive Bifidobacterium infantis.FEMS microbiology ecology · 2021Article
- Nitrogen form, concentration, and micronutrient availability affect microcystin production in cyanobacterial blooms.Harmful algae · 2021Article
- Entomotoxicity of jaburetox: revisiting the neurotoxic mechanisms in insects.Journal of venom research · 2020Review
- Emergence of metal selectivity and promiscuity in metalloenzymes.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2019Review
- Ureases: Historical aspects, catalytic, and non-catalytic properties - A review.Journal of advanced research · 2018Review
- A Bacillus paralicheniformis Iron-Containing Urease Reduces Urea Concentrations in Rice Wine.Applied and environmental microbiology · 2017Article
- Structure/function correlations over binuclear non-heme iron active sites.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2016Review
- Promiscuity in the Enzymatic Catalysis of Phosphate and Sulfate Transfer.Biochemistry · 2016Review
- Evolution of Macromolecular Docking Techniques: The Case Study of Nickel and Iron Metabolism in Pathogenic Bacteria.Molecules (Basel, Switzerland) · 2015Review
- Andrographolide sodium bisulphite-induced inactivation of urease: inhibitory potency, kinetics and mechanism.BMC complementary and alternative medicine · 2015Article
- Complete Genome Sequences of Two Helicobacter pylori Strains from a Canadian Arctic Aboriginal Community.Genome announcements · 2015Article
- Nonredox nickel enzymes.Chemical reviews · 2014Review
- Nickel-dependent metalloenzymes.Archives of biochemistry and biophysics · 2014Review
- Predicting copper-, iron-, and zinc-binding proteins in pathogenic species of the Paracoccidioides genus.Frontiers in microbiology · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Helicobacter mustelae, a gastric pathogen of ferrets, synthesizes a distinct iron-dependent urease in addition to its archetypical nickel-containing enzyme. The iron-urease is oxygen-labile, with the inactive protein exhibiting a methemerythrin-like electronic spectrum. Significantly, incubation of the oxidized protein with dithionite under anaerobic conditions leads to restoration of activity and bleaching of the spectrum. Structural analysis of the oxidized species reveals a dinuclear iron metallocenter bridged by a lysine carbamate, closely resembling the traditional nickel-urease active site. Although the iron-urease is less active than the nickel-enzyme, its activity allows H. mustelae to survive the carnivore's low-nickel gastric environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.