ArticleInvestigative ophthalmology & visual science2011
Identification of multipotent stem/progenitor cells in murine sclera.
Article in Investigative ophthalmology & visual science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Sparse Cell Labeling Reveals Morphologic Diversity Among Mouse Scleral Fibroblasts.Investigative ophthalmology & visual science · 2026Article
- Timp2-modified gelatinhydroxyphenylpropionic acid hydrogels reverse enhanced scleral recovery and suppress myopia development in mice.Materials today. Bio · 2025Article
- Distinct Transcriptomic Profiles of Cultured Anterior and Posterior Populations of Human Infant Scleral Fibroblasts: Including Dopamine Receptors.Investigative ophthalmology & visual science · 2025Article
- Myopia development: multifactorial interplay, molecular mechanisms and possible strategies.Frontiers in medicine · 2025Review
- Nonhematopoietic Stem Cell Identification and Sorting in Adult Retina.Methods in molecular biology (Clifton, N.J.) · 2025Article
- RAD21 deficiency drives corneal to scleral differentiation fate switching via upregulating WNT9B.iScience · 2024Article
- Biofabrication of Artificial Stem Cell Niches in the Anterior Ocular Segment.Bioengineering (Basel, Switzerland) · 2021Review
- Effects of carbon and nitrogen plasma immersion ion implantation on bioactivity of zirconia.RSC advances · 2020Article
- Dasatinib inhibits peripapillary scleral myofibroblast differentiation.Experimental eye research · 2020Article
- Concise Review: Using Stem Cells to Prevent the Progression of Myopia-A Concept.Stem cells (Dayton, Ohio) · 2015Review
- Upregulation of BMSCs osteogenesis by positively-charged tertiary amines on polymeric implants via charge/iNOS signaling pathway.Scientific reports · 2015Article
- Chondrogenesis in scleral stem/progenitor cells and its association with form-deprived myopia in mice.Molecular vision · 2015Article
- Regulation of scleral fibroblast differentiation by bone morphogenetic protein-2.International journal of ophthalmology · 2014Review
- Ocular stem cells: a status update!Stem cell research & therapy · 2014Review
- Evaluation of gene expression profiles and pathways underlying postnatal development in mouse sclera.Molecular vision · 2012Article
- Distribution of Stromal Cell Subsets in Cultures from Distinct Ocular Surface Compartments.Journal of ophthalmic & vision researchArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeThe sclera forms the fibrous outer coat of the eyeball and acts as a supportive framework. The purpose of this study was to examine whether the sclera contains mesenchymal stem/progenitor cells.
methodScleral tissue from C57BL6/J mice was separated from the retina and choroid and subsequently enzyme digested to release single cells. Proliferation capacity, self-renewal capacity, and ability for multipotent differentiation were analyzed by BrdU labeling, flow cytometry, reverse transcriptase-polymerase chain reaction, immunocytochemistry, and in vivo transplantation.
resultsThe scleral stem/progenitor cells (SSPCs) possessed clonogenic and high doubling capacities. These cells were positive for the mesenchymal markers Sca-1, CD90.2, CD44, CD105, and CD73 and negative for the hematopoietic markers CD45, CD11b, Flk1, CD34, and CD117. In addition to expressing stem cell genes ABCG2, Six2, Notch1, and Pax6, SSPCs were able to differentiate to adipogenic, chondrogenic, and neurogenic lineages.
conclusionsThis study indicates that the sclera contains multipotent mesenchymal stem cells. Further study of SSPCs may help elucidate the cellular and molecular mechanism of scleral diseases such as scleritis and myopia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.