ArticleInfection and immunity2011
Coinfection with Enterohepatic Helicobacter species can ameliorate or promote Helicobacter pylori-induced gastric pathology in C57BL/6 mice.
Article in Infection and immunity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 47 citations in OpenAlex.
- Review
- Review
- Role of the Gastric Microbiome in Gastric Cancer: From Carcinogenesis to Treatment.Frontiers in microbiology · 2021Review
- Male-Dependent Promotion of Colitis in 129International journal of molecular sciences · 2020Article
- Helicobacter pylori-infected C57BL/6 mice with different gastrointestinal microbiota have contrasting gastric pathology, microbial and host immune responses.Scientific reports · 2018Article
- Overview of Current Concepts in Gastric Intestinal Metaplasia and Gastric Cancer.Gastroenterology & hepatology · 2018Article
- The gastric microbiome, its interaction with Helicobacter pylori, and its potential role in the progression to stomach cancer.PLoS pathogens · 2017Review
- Attenuation ofGut pathogens · 2017Article
- Novel Helicobacter species H.japonicum isolated from laboratory mice from Japan induces typhlocolitis and lower bowel carcinoma in C57BL/129 IL10-/- mice.Carcinogenesis · 2016Article
- Different gastric microbiota compositions in two human populations with high and low gastric cancer risk in Colombia.Scientific reports · 2016Article
- Pathobiology of Helicobacter pylori-Induced Gastric Cancer.Gastroenterology · 2016Review
- Association of seropositivity to Helicobacter species and biliary tract cancer in the ATBC study.Hepatology (Baltimore, Md.) · 2014Article
- Pathogenic properties of enterohepatic Helicobacter spp. isolated from rhesus macaques with intestinal adenocarcinoma.Journal of medical microbiology · 2014Article
- Gastrointestinal malignancy and the microbiome.Gastroenterology · 2014Review
- Helminth co-infection in Helicobacter pylori infected INS-GAS mice attenuates gastric premalignant lesions of epithelial dysplasia and glandular atrophy and preserves colonization resistance of the stomach to lower bowel microbiota.Microbes and infection · 2014Article
- Article
- Dietary factors modulate Helicobacter-associated gastric cancer in rodent models.Toxicologic pathology · 2014Article
- The degree of Helicobacter pylori-triggered inflammation is manipulated by preinfection host microbiota.Infection and immunity · 2013Article
- Mouse models of gastric cancer.Cancers · 2013Article
- Systemic macrophage depletion inhibits Helicobacter bilis-induced proinflammatory cytokine-mediated typhlocolitis and impairs bacterial colonization dynamics in a BALB/c Rag2-/- mouse model of inflammatory bowel disease.Infection and immunity · 2012Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
To investigate how different enterohepatic Helicobacter species (EHS) influence Helicobacter pylori gastric pathology, C57BL/6 mice were infected with Helicobacter hepaticus or Helicobacter muridarum, followed by H. pylori infection 2 weeks later. Compared to H. pylori-infected mice, mice infected with H. muridarum and H. pylori (HmHp mice) developed significantly lower histopathologic activity index (HAI) scores (P < 0.0001) at 6 and 11 months postinoculation (MPI). However, mice infected with H. hepaticus and H. pylori (HhHp mice) developed more severe gastric pathology at 6 MPI (P = 0.01), with a HAI at 11 MPI (P = 0.8) similar to that of H. pylori-infected mice. H. muridarum-mediated attenuation of gastritis in coinfected mice was associated with significant downregulation of proinflammatory Th1 (interlukin-1beta [Il-1β], gamma interferon [Ifn-γ], and tumor necrosis factor-alpha [Tnf-α]) cytokines at both time points and Th17 (Il-17A) cytokine mRNA levels at 6 MPI in murine stomachs compared to those of H. pylori-infected mice (P < 0.01). Coinfection with H. hepaticus also suppressed H. pylori-induced elevation of gastric Th1 cytokines Ifn-γ and Tnf-α (P < 0.0001) but increased Th17 cytokine mRNA levels (P = 0.028) at 6 MPI. Furthermore, mRNA levels of Il-17A were positively correlated with the severity of helicobacter-induced gastric pathology (HhHp>H. pylori>HmHp) (at 6 MPI, r² = 0.92, P < 0.0001; at 11 MPI, r² = 0.82, P < 0.002). Despite disparate effects on gastritis, colonization levels of gastric H. pylori were increased in HhHp mice (at 6 MPI) and HmHp mice (at both time points) compared to those in mono-H. pylori-infected mice. These data suggest that despite consistent downregulation of Th1 responses, EHS coinfection either attenuated or promoted the severity of H. pylori-induced gastric pathology in C57BL/6 mice. This modulation was related to the variable effects of EHS on gastric interleukin 17 (IL-17) responses to H. pylori infection.
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