ArticlePlant physiology2011
Analysis of a range of catabolic mutants provides evidence that phytanoyl-coenzyme A does not act as a substrate of the electron-transfer flavoprotein/electron-transfer flavoprotein:ubiquinone oxidoreductase complex in Arabidopsis during dark-induced senescence.
Article in Plant physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- The diversity of substrates for plant respiration and how to optimize their use.Plant physiology · 2023Review
- A systematicFrontiers in plant science · 2023Article
- Metabolic control of arginine and ornithine levels paces the progression of leaf senescence.Plant physiology · 2022Article
- Genome-wide association of the metabolic shifts underpinning dark-induced senescence in Arabidopsis.The Plant cell · 2022Article
- Transcriptional Regulation and Signaling of Developmental Programmed Cell Death in Plants.Frontiers in plant science · 2021Review
- Bioinformatics Resources for Plant Abiotic Stress Responses: State of the Art and Opportunities in the Fast Evolving -Omics Era.Plants (Basel, Switzerland) · 2020Review
- PheophorbidePlant physiology · 2020Article
- TAT1 and TAT2 tyrosine aminotransferases have both distinct and shared functions in tyrosine metabolism and degradation inThe Journal of biological chemistry · 2019Article
- Molecular Mechanisms Preventing Senescence in Response to Prolonged Darkness in a Desiccation-Tolerant Plant.Plant physiology · 2018Article
- Snf1-RELATED KINASE1-Controlled C/SThe Plant cell · 2018Article
- Down-regulation of tomato PHYTOL KINASE strongly impairs tocopherol biosynthesis and affects prenyllipid metabolism in an organ-specific manner.Journal of experimental botany · 2016Article
- Integrative Approaches to Enhance Understanding of Plant Metabolic Pathway Structure and Regulation.Plant physiology · 2015Article
- Transcription Factor Arabidopsis Activating Factor1 Integrates Carbon Starvation Responses with Trehalose Metabolism.Plant physiology · 2015Article
- Evolution and functional implications of the tricarboxylic acid cycle as revealed by phylogenetic analysis.Genome biology and evolution · 2014Article
- On the role of plant mitochondrial metabolism and its impact on photosynthesis in both optimal and sub-optimal growth conditions.Photosynthesis research · 2014Review
- The use of metabolomics to dissect plant responses to abiotic stresses.Cellular and molecular life sciences : CMLS · 2012Review
- Antisense inhibition of the 2-oxoglutarate dehydrogenase complex in tomato demonstrates its importance for plant respiration and during leaf senescence and fruit maturation.The Plant cell · 2012Article
- Model-based confirmation of alternative substrates of mitochondrial electron transport chain.The Journal of biological chemistry · 2012Article
- Functional genomics tools applied to plant metabolism: a survey on plant respiration, its connections and the annotation of complex gene functions.Frontiers in plant science · 2012Article
- Co-expression and co-responses: within and beyond transcription.Frontiers in plant science · 2012Article
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Authors and funding
12 authors at 4 institutions in 4 countries.
Funding
Abstract
The process of dark-induced senescence in plants is not fully understood, however, the functional involvement of an electron-transfer flavoprotein/electron-transfer flavoprotein:ubiquinone oxidoreductase (ETF/ETFQO), has been demonstrated. Recent studies have revealed that the enzymes isovaleryl-coenzyme A (CoA) dehydrogenase and 2-hydroxyglutarate dehydrogenase act as important electron donors to this complex. In addition both enzymes play a role in the breakdown of cellular carbon storage reserves with isovaleryl-CoA dehydrogenase being involved in degradation of the branched-chain amino acids, phytol, and lysine while 2-hydroxyglutarate dehydrogenase is exclusively involved in lysine degradation. Given that the chlorophyll breakdown intermediate phytanoyl-CoA accumulates dramatically both in knockout mutants of the ETF/ETFQO complex and of isovaleryl-CoA dehydrogenase following growth in extended dark periods we have investigated the direct importance of chlorophyll breakdown for the supply of carbon and electrons during this process. For this purpose we isolated three independent Arabidopsis (Arabidopsis thaliana) knockout mutants of phytanoyl-CoA 2-hydroxylase and grew them under the same extended darkness regime as previously used. Despite the fact that these mutants accumulated phytanoyl-CoA and also 2-hydroxyglutarate they exhibited no morphological changes in comparison to the other mutants previously characterized. These results are consistent with a single entry point of phytol breakdown into the ETF/ETFQO system and furthermore suggest that phytol is not primarily metabolized by this pathway. Furthermore analysis of isovaleryl-CoA dehydrogenase/2-hydroxyglutarate dehydrogenase double mutants generated here suggest that these two enzymes essentially account for the entire electron input via the ETF complex.
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