ArticleThe Journal of physiology2011
Recovery of proprioceptive feedback from nerve crush.
Article in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- An assessment of co-contraction in reinnervated muscle.Regenerative medicine · 2024Article
- Modulation of central synapse remodeling after remote peripheral injuries by the CCL2-CCR2 axis and microglia.Cell reports · 2024Article
- Article
- Delayed Onset Muscle Soreness and Critical Neural Microdamage-Derived Neuroinflammation.Biomolecules · 2022Review
- Calcium homeostasis in parvalbumin DRG neurons is altered after sciatic nerve crush and sciatic nerve transection injuries.Journal of neurophysiology · 2021Article
- Neuregulin 1 Drives Morphological and Phenotypical Changes in C2C12 Myotubes: TowardsFrontiers in cell and developmental biology · 2021Article
- Synaptic Plasticity on Motoneurons After Axotomy: A Necessary Change in Paradigm.Frontiers in molecular neuroscience · 2020Review
- Adaptation of muscle activation after patellar loading demonstrates neural control of joint variables.Scientific reports · 2019Article
- Effects of Repeated 20-Hz Electrical Stimulation on Functional Recovery Following Peripheral Nerve Injury.Neurorehabilitation and neural repair · 2019Article
- VGLUT1 synapses and P-boutons on regenerating motoneurons after nerve crush.The Journal of comparative neurology · 2017Article
- Distribution of TTX-sensitive voltage-gated sodium channels in primary sensory endings of mammalian muscle spindles.Journal of neurophysiology · 2017Article
- Activity-dependent redistribution of Kv2.1 ion channels on rat spinal motoneurons.Physiological reports · 2016Article
- Complex impairment of IA muscle proprioceptors following traumatic or neurotoxic injury.Journal of anatomy · 2015Article
- Redistribution of Kv2.1 ion channels on spinal motoneurons following peripheral nerve injury.Brain research · 2014Article
- Swimming against the tide: investigations of the C-bouton synapse.Frontiers in neural circuits · 2014Review
- Expression of postsynaptic Ca2+-activated K+ (SK) channels at C-bouton synapses in mammalian lumbar -motoneurons.The Journal of physiology · 2013Article
- Generating intrafusal skeletal muscle fibresJournal of tissue engineeringReview
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 2 countries.
Funding
Abstract
Sensorimotor functions are restored by peripheral nerve regeneration with greater success following injuries that crush rather than sever the nerve. Better recovery following nerve crush is commonly attributed to superior reconnection of regenerating axons with their original peripheral targets. The present study was designed to estimate the fraction of stretch reflex recovery attributable to functional recovery of regenerated spindle afferents. Recovery of the spindle afferent population was estimated from excitatory postsynaptic potentials evoked by muscle stretch (strEPSPs) in motoneurons. These events were measured in cats that were anaesthetized, so that recovery of spindle afferent function, including both muscle stretch encoding and monosynaptic transmission, could be separated from other factors that act centrally to influence muscle stretch-evoked excitation of motoneurons. Recovery of strEPSPs to 70% of normal specified the extent of overall functional recovery by the population spindle afferents that regained responsiveness to muscle stretch. In separate studies, we examined recovery of the stretch reflex in decerebrate cats, and found that it recovered to supranormal levels after nerve crush. The substantial disparity in recovery between strEPSPs and stretch reflex led us to conclude that factors in addition to recovery of spindle afferents make a large contribution in restoring the stretch reflex following nerve crush.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.