ReviewPediatrics2011
Automated dose-rounding recommendations for pediatric medications.
Review in Pediatrics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Parenteral Protein Decision Support System Improves Protein Delivery in Preterm Infants: A Randomized Clinical Trial.JPEN. Journal of parenteral and enteral nutrition · 2018Trial
- Preventing Medication Errors in Paediatrics: A Narrative Review.Clinical medicine insights. Pediatrics · 2026Review
- Creating Meaningful Alerts and Reducing Alert Fatigue: Strategies Implemented by Informatics Pharmacists to Optimize Dose Range Checking Alerts in a Multihospital Health System.The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians · 2022Article
- Evaluation of a Pharmacist-Driven Pediatric Dose Rounding Protocol.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2022Article
- Strategies for Implementing Pediatric Dose Standardization: Considerations From the Vizient University Health System Consortium Pharmacy Network Pediatric Pharmacy Committee.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2022Article
- Implementation of a Standardized Approach to Improve the Pediatric Discharge Medication Process.Pediatrics · 2021Article
- Caregiver Medication Management and Understanding After Pediatric Hospital Discharge.Hospital pediatrics · 2019Article
- Development of a consensus-base list of criteria for prescribing medication in a pediatric population.International journal of clinical pharmacy · 2015Article
- Meaningful Use of Electronic Health Records: Experiences From the Field and Future Opportunities.JMIR medical informatics · 2015Article
- Standard dose development for medications commonly used in the neonatal intensive care unit.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2014Article
- Appropriateness of commercially available and partially customized medication dosing alerts among pediatric patients.Journal of the American Medical Informatics Association : JAMIA · 2014Article
- Rounding of birth weights in a neonatal intensive care unit over 20 years: an analysis of a large cohort study.BMJ open · 2013Article
- Prevalence of Unrounded Medication Doses and Associated Factors Among Hospitalized Pediatric Patients.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAGArticle
- Computerized clinical decision support for medication prescribing and utilization in pediatrics.Journal of the American Medical Informatics Association : JAMIAReview
- Dose-Banding of Intravenous Piperacillin-Tazobactam in Pediatric Surgical Inpatients.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAGArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundAlthough pediatric electronic prescribing systems are increasingly being used in pediatric care, many of these systems lack the clinical decision-support infrastructure needed to calculate a safe and effective rounded medication dose. This infrastructure is required to facilitate tailoring of established dosing guidance while maintaining the medication's therapeutic intent.
objectiveThe goal of this project was to establish best practices for generating an appropriate medication dose and to create an interoperable rounding knowledge base combining best practices and dose-rounding information.
methodsWe interviewed 19 pediatric health care and pediatric pharmacy experts and conducted a literature review. After using these data to construct initial rounding tolerances, we used a Delphi process to achieve consensus about the rounding tolerance for each commonly prescribed medication.
resultsThree categories for medication-rounding philosophy emerged from our literature review: (1) medications for which rounding is used judiciously to retain the intended effect; (2) medications that are rounded with attention to potential unintended effects; and (3) medications that are rarely rounded because of the potential for toxicity. We assigned a small subset of medications to a fourth category-inadequate data-for which there was insufficient information to provide rounding recommendations. For all 102 medications, we were able to arrive at a consensus recommendation for rounding a given calculated dose.
conclusionsResults of this study provide the pediatric information technology community with a primary set of recommended rounding tolerances for commonly prescribed drugs. The interoperable knowledge base developed here can be integrated with existing and developing electronic prescribing systems, potentially improving prescribing safety and reducing cognitive workload.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.