ReviewMolecular and cellular endocrinology2012
Clocks on top: the role of the circadian clock in the hypothalamic and pituitary regulation of endocrine physiology.
Review in Molecular and cellular endocrinology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Modulation of cerebrospinal fluid secretion facilitated by serotonergic and noradrenergic receptors in the rat choroid plexus.Fluids and barriers of the CNS · 2025Article
- Daily Brain Metabolic Rhythms of Wild Nocturnal Bats.International journal of molecular sciences · 2024Article
- Chrono-Endocrinology in Clinical Practice: A Journey from Pathophysiological to Therapeutic Aspects.Life (Basel, Switzerland) · 2024Review
- Differential Expression of Circadian Clock Genes in the Bovine Neuroendocrine Adrenal System.Genes · 2023Article
- The role of the circadian rhythms in critical illness with a focus on acute pancreatitis.Heliyon · 2023Review
- A link between migraine and prolactin: the way forward.Future science OA · 2021Review
- Vasopressinergic Activity of the Suprachiasmatic Nucleus and mRNA Expression of Clock Genes in the Hypothalamus-Pituitary-Gonadal Axis in Female Aging.Frontiers in endocrinology · 2021Article
- Genome-wide screening of circadian and non-circadian impact of Neat1 genetic deletion.Computational and structural biotechnology journal · 2021Article
- Exposure to Artificial Light at Night and the Consequences for Flora, Fauna, and Ecosystems.Frontiers in neuroscience · 2020Review
- Circadian Function in Multiple Cell Types Is Necessary for Proper Timing of the Preovulatory LH Surge.Journal of biological rhythms · 2019Article
- Sleep and circadian disruption and incident breast cancer risk: An evidence-based and theoretical review.Neuroscience and biobehavioral reviews · 2018Review
- Rhythms in the endocrine system of fish: a review.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2017Review
- Unilaterally blocking the muscarinic receptors in the suprachiasmatic nucleus in proestrus rats prevents pre-ovulatory LH secretion and ovulation.Reproductive biology and endocrinology : RB&E · 2016Article
- The Glymphatic System: A Beginner's Guide.Neurochemical research · 2015Review
- Article
- Thyroxine differentially modulates the peripheral clock: lessons from the human hair follicle.PloS one · 2015Article
- Dissection of glucocorticoid receptor-mediated inhibition of the hypothalamic-pituitary-adrenal axis by gene targeting in mice.Frontiers in neuroendocrinology · 2015Review
- Episodic hormone secretion: a comparison of the basis of pulsatile secretion of insulin and GnRH.Endocrine · 2014Review
- A meeting of two chronobiological systems: circadian proteins Period1 and BMAL1 modulate the human hair cycle clock.The Journal of investigative dermatology · 2014Article
- Sex differences in circadian timing systems: implications for disease.Frontiers in neuroendocrinology · 2014Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Recent strides in circadian biology over the last several decades have allowed researchers new insight into how molecular circadian clocks influence the broader physiology of mammals. Elucidation of transcriptional feedback loops at the heart of endogenous circadian clocks has allowed for a deeper analysis of how timed cellular programs exert effects on multiple endocrine axes. While the full understanding of endogenous clocks is currently incomplete, recent work has re-evaluated prior findings with a new understanding of the involvement of these cellular oscillators, and how they may play a role in constructing rhythmic hormone synthesis, secretion, reception, and metabolism. This review addresses current research into how multiple circadian clocks in the hypothalamus and pituitary receive photic information from oscillators within the hypothalamic suprachiasmatic nucleus (SCN), and how resultant hypophysiotropic and pituitary hormone release is then temporally gated to produce an optimal result at the cognate target tissue. Special emphasis is placed not only on neural communication among the SCN and other hypothalamic nuclei, but also how endogenous clocks within the endocrine hypothalamus and pituitary may modulate local hormone synthesis and secretion in response to SCN cues. Through evaluation of a larger body of research into the impact of circadian biology on endocrinology, we can develop a greater appreciation into the importance of timing in endocrine systems, and how understanding of these endogenous rhythms can aid in constructing appropriate therapeutic treatments for a variety of endocrinopathies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.