ArticleNeuroscience and biobehavioral reviews2012
Psychoneuroimmunology in pregnancy: immune pathways linking stress with maternal health, adverse birth outcomes, and fetal development.
Article in Neuroscience and biobehavioral reviews, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03018132 (The PROVIDE Study; Preeclampsia Research on Vitamin D, Inflammation, & Depression), which is not on this map. Cited by 89 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The PROVIDE Study; Preeclampsia Research on Vitamin D, Inflammation, & Depression
Who cites it
89 citing papers in PubMed, 2 syntheses or guidelines pooled it, 188 citations in OpenAlex.
- Perinatal mortality and its association with antenatal care visit, maternal tetanus toxoid immunization and partograph utilization in Ethiopia: a meta-analysis.Scientific reports · 2021Pooled it
- Racial Discrimination and Adverse Birth Outcomes: An Integrative Review.Journal of midwifery & women's health · 2016Pooled it
- Inflammatory markers in serum and placenta in a randomized controlled trial of group prenatal care.American journal of obstetrics & gynecology MFM · 2023Trial
- Socioeconomic disadvantage, gestational immune activity, and neurodevelopment in early childhood.Proceedings of the National Academy of Sciences of the United States of America · 2017Trial
- Immunological maladaptation preceding spontaneous preterm birth in human pregnancies.Nature communications · 2026Article
- Associations of multiple dimensions of socioeconomic status with adverse pregnancy outcomes.Pregnancy (Hoboken, N.J.) · 2025Article
- Exploring Neurobiological and Pharmacological Dimensions of Psychological Distress in Pre-Eclampsia: Implications for Maternal and Neonatal Outcomes.Health science reports · 2025Article
- Article
- Prenatal inflammation and trauma symptoms in Latina mothers: The role of discrimination and growing up in an ethnic minoritized context.Brain, behavior, & immunity - health · 2025Article
- Association between pre-pregnancy maternal stress and small for gestational age: a population-based retrospective cohort study.BMC medicine · 2025Article
- The interaction of second trimester prenatal maternal inflammation and psychosocial stress on offspring depressive symptoms in adolescence.Brain behavior and immunity integrative · 2024Article
- Patient and community centered approaches to sepsis among birthing people.Seminars in perinatology · 2024Review
- Exposure to family and domestic violence in the prenatal period is associated with an increased risk of hospitalization for bronchiolitis in children under 2 years.Journal of public health (Oxford, England) · 2024Article
- Gestational exposure to organochlorine compounds and metals and infant birth weight: effect modification by maternal hardships.Environmental health : a global access science source · 2024Article
- Gendered Racism in Pregnancy and Stress among Women in the United States during the COVID-19 Pandemic.International perspectives in psychology : research, practice, consultation · 2024Article
- Linking Adverse Experiences to Pregnancy and Birth Outcomes: A Life Course Analysis of Racial and Ethnic Disparities Among Low-Income Women.Journal of racial and ethnic health disparities · 2024Article
- Prenatal mood and anxiety disorders and associated cytokine changes.Journal of affective disorders · 2024Article
- Neighborhood racial composition and experiences of racial discrimination: Associations with cytokines during pregnancy among African American women.Brain, behavior, & immunity - health · 2024Article
- Regulatory T-cell phenotypes in prenatal psychological distress.Brain, behavior, and immunity · 2024Article
- Quercetin Increases Growth Performance and Decreases Incidence of Diarrhea and Mechanism of Action in Weaned Piglets.Oxidative medicine and cellular longevity · 2024Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
It is well-established that psychological stress promotes immune dysregulation in nonpregnant humans and animals. Stress promotes inflammation, impairs antibody responses to vaccination, slows wound healing, and suppresses cell-mediated immune function. Importantly, the immune system changes substantially to support healthy pregnancy, with attenuation of inflammatory responses and impairment of cell-mediated immunity. This adaptation is postulated to protect the fetus from rejection by the maternal immune system. Thus, stress-induced immune dysregulation during pregnancy has unique implications for both maternal and fetal health, particularly preterm birth. However, very limited research has examined stress-immune relationships in pregnancy. The application of psychoneuroimmunology research models to the perinatal period holds great promise for elucidating biological pathways by which stress may affect adverse pregnancy outcomes, maternal health, and fetal development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.