ArticleDevelopmental biology2011
miR-196 regulates axial patterning and pectoral appendage initiation.
Article in Developmental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
42 citing papers in PubMed.
- Insights into Craniofacial Development and Anomalies: Exploring Fgf Signaling in Zebrafish Models.Current osteoporosis reports · 2024Review
- The expanding roles of Nr6a1 in development and evolution.Frontiers in cell and developmental biology · 2024Review
- Prominent caudal shift of the lumbar plexus roots in spines with 18 thoracolumbar vertebrae.Surgical and radiologic anatomy : SRA · 2023Article
- Roles of miR-196a and miR-196b in Zebrafish Motor Function.Biomolecules · 2023Article
- microRNA regulation of skin pigmentation in golden-back mutant of crucian carp from a rice-fish integrated farming system.BMC genomics · 2023Article
- HOX epimutations driven by maternal SMCHD1/LRIF1 haploinsufficiency trigger homeotic transformations in genetically wildtype offspring.Nature communications · 2022Article
- MicroRNA-129-5p promotes proliferation and metastasis of hepatocellular carcinoma by regulating the BMP2 gene.Experimental and therapeutic medicine · 2021Article
- AGO unchained: Canonical and non-canonical roles of Argonaute proteins in mammals.Frontiers in bioscience (Landmark edition) · 2020Review
- Methylmercury Epigenetics.Toxics · 2019Review
- A novel conserved enhancer at zebrafish zic3 and zic6 loci drives neural expression.Developmental dynamics : an official publication of the American Association of Anatomists · 2019Article
- MicroRNA-196a links human body fat distribution to adipose tissue extracellular matrix composition.EBioMedicine · 2019Article
- Inventory of European Sea Bass (Frontiers in genetics · 2019Article
- MicroRNA and Human Bone Health.JBMR plus · 2019Review
- Mudskippers and Their Genetic Adaptations to an Amphibious Lifestyle.Animals : an open access journal from MDPI · 2018Review
- Integrative analysis of the Pekin duck (Anas anas) MicroRNAome during feather follicle development.BMC developmental biology · 2017Article
- A Constitutive Intrinsic Inflammatory Signaling Circuit Composed of miR-196b, Meis2, PPP3CC, and p65 Drives Prostate Cancer Castration Resistance.Molecular cell · 2017Article
- Up-regulation of ribosome biogenesis by MIR196A2 genetic variation promotes endometriosis development and progression.Oncotarget · 2016Article
- Dynamic mRNA and miRNA expression analysis in response to intermuscular bone development of blunt snout bream (Megalobrama amblycephala).Scientific reports · 2016Article
- Nucleic Acid Templated Chemical Reaction in a Live Vertebrate.ACS central science · 2016Article
- In silico genome wide mining of conserved and novel miRNAs in the brain and pineal gland of Danio rerio using small RNA sequencing data.Genomics data · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Vertebrate Hox clusters contain protein-coding genes that regulate body axis development and microRNA (miRNA) genes whose functions are not yet well understood. We overexpressed the Hox cluster microRNA miR-196 in zebrafish embryos and found four specific, viable phenotypes: failure of pectoral fin bud initiation, deletion of the 6th pharyngeal arch, homeotic aberration and loss of rostral vertebrae, and reduced number of ribs and somites. Reciprocally, miR-196 knockdown evoked an extra pharyngeal arch, extra ribs, and extra somites, confirming endogenous roles of miR-196. miR-196 injection altered expression of hox genes and the signaling of retinoic acid through the retinoic acid receptor gene rarab. Knocking down rarab mimicked the pectoral fin phenotype of miR-196 overexpression, and reporter constructs tested in tissue culture and in embryos showed that the rarab 3'UTR is a miR-196 target for pectoral fin bud initiation. These results show that a Hox cluster microRNA modulates development of axial patterning similar to nearby protein-coding Hox genes, and acts on appendicular patterning at least in part by modulating retinoic acid signaling.
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Registered trials
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