ReviewCurrent protein & peptide science2011
Small open reading frames: current prediction techniques and future prospect.
Review in Current protein & peptide science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 53 citations in OpenAlex.
- Computational identification and characterization of noncoding RNA-encoded peptides: tools, databases, and in silico strategies.Amino acids · 2026Review
- Article
- Mutational constraint analysis workflow for overlapping short open reading frames and genomic neighbors.BMC genomics · 2025Article
- Discovering the hidden function in fungal genomes.Nature communications · 2024Review
- LncRNA-encoded peptides in cancer.Journal of hematology & oncology · 2024Review
- Review
- Integrated sequence and -omic features reveal novel small proteome ofFrontiers in microbiology · 2024Article
- Re-evaluating the impact of alternative RNA splicing on proteomic diversity.Frontiers in genetics · 2023Review
- Short open reading frames (sORFs) and microproteins: an update on their identification and validation measures.Journal of biomedical science · 2022Review
- Small open reading frames in plant research: from prediction to functional characterization.3 Biotech · 2022Review
- At elevated temperatures, heat shock protein genes show altered ratios of different RNAs and expression of new RNAs, including several novel HSPB1 mRNAs encoding HSP27 protein isoforms.Experimental and therapeutic medicine · 2021Article
- The cardiac translational landscape reveals that micropeptides are new players involved in cardiomyocyte hypertrophy.Molecular therapy : the journal of the American Society of Gene Therapy · 2021Article
- OpenProt 2021: deeper functional annotation of the coding potential of eukaryotic genomes.Nucleic acids research · 2021Article
- The how and why of lncRNA function: An innate immune perspective.Biochimica et biophysica acta. Gene regulatory mechanisms · 2020Review
- CPPred: coding potential prediction based on the global description of RNA sequence.Nucleic acids research · 2019Article
- Recognition of the polycistronic nature of human genes is critical to understanding the genotype-phenotype relationship.Genome research · 2018Review
- Identifying New Small Proteins in Escherichia coli.Proteomics · 2018Article
- Review
- Beyond mRNA: The role of non-coding RNAs in normal and aberrant hematopoiesis.Molecular genetics and metabolism · 2017Review
- Discovery and characterization of smORF-encoded bioactive polypeptides.Nature chemical biology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Evidence is accumulating that small open reading frames (sORF, <100 codons) play key roles in many important biological processes. Yet, they are generally ignored in gene annotation despite they are far more abundant than the genes with more than 100 codons. Here, we demonstrate that popular homolog search and codon-index techniques perform poorly for small genes relative to that for larger genes, while a method dedicated to sORF discovery has a similar level of accuracy as homology search. The result is largely due to the small dataset of experimentally verified sORF available for homology search and for training ab initio techniques. It highlights the urgent need for both experimental and computational studies in order to further advance the accuracy of sORF prediction.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.