Evidence map›Paper›PMID 21787120›Full record

ReviewCritical reviews in biochemistry and molecular biology2011

Defining genome maintenance pathways using functional genomic approaches.

Carol E Bansbach, David Cortez

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Critical reviews in biochemistry and molecular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Genome maintenance and human longevity.Current opinion in genetics & development · 2014
    Review
  4. DNA damage response: three levels of DNA repair regulation.Cold Spring Harbor perspectives in biology · 2013
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Carol E BansbachDepartment of Biochemistry, Vanderbilt University School of Medicine, Light Hall, Nashville, TN 37232, USA.
David Cortez

Funding

Functional Analysis of Replication Stress Response ProteinsR01CA136933 · NCI · VANDERBILT UNIVERSITY · PI CORTEZ, DAVID K · 2009 to 2013
$1.6M
Automated Microscope for Long-Duration, Quantitative Dynamic ImagingS10RR027485 · NCRR · VANDERBILT UNIVERSITY · PI WIKSWO, JOHN PETER · 2010 to 2010
$500k
NCI NIH HHS CA06485NCI NIH HHS CA136933NCI NIH HHS R01 CA136933NCRR NIH HHS S10 RR027485
6 · The paper itself

Abstract

Genome maintenance activities including DNA repair, cell division cycle control, and checkpoint signaling pathways preserve genome integrity and prevent disease. Defects in these pathways cause birth defects, neurodegeneration, premature aging, and cancer. Recent technical advances in functional genomic approaches such as expression profiling, proteomics, and RNA interference (RNAi) technologies have rapidly expanded our knowledge of the proteins that work in these pathways. In this review, we examine the use of these high-throughput methodologies in higher eukaryotic organisms for the interrogation of genome maintenance activities.

Indexed as

DNA RepairGenome, HumanSignal TransductionAnimalsCell Cycle ProteinsChromatinDNA-Binding ProteinsDNA DamageDNA ReplicationGene Expression ProfilingHumansMass SpectrometryProtein Array AnalysisProtein Interaction MappingProtein Processing, Post-TranslationalProteomicsCell Cycle ProteinsChromatinDNA-Binding Proteins

Identifiers

PMID21787120
PMCPMC3144553

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.